::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY TO DETERMINE THE PATTERN OF PRIMARY GLOMERULONEPHRITIS IN PAKISTAN

AUTHORS:

Dr Ans Dastgir, Dr Aazib Irshad, Dr Saima Khan

ABSTRACT:

Introduction: Glomerulonephritis is classified into several different pathological patterns, which are generally divided into non-proliferative or proliferative types. Glomerulonephritis accounts for 25-45% of cases of end-stage renal disease (ESRD) in developing countries. The aim of this study is to determine the type of glomerulonephritis among inpatients and outpatients of the nephrology unit to reflect the pattern of glomerulonephritis. Place and Duration: The study was conducted at the Nephrology department of Jinnah Hospital Lahore for one-year duration from June 2019 to June 2020 to determine the type and percentage of primary glomerulonephritis reflecting the pattern of glomerulonephritis in the Pakistani population. Methods: The current study duration was 12 months, and 128 patients with glomerulonephritis were enrolled in the study. Statistical analysis was performed using the Statistical Package for Social Sciences. In the present study, it was observed that the majority (31.3%) of patients were aged 31 to 40 years, and the mean ± SD age was 32.94 ± 12.66 years, ranging from 18 to 70 years. Results: The present study found that 64.8% were male and 35.2% female. The male-to-female ratio was 1.8: 1. Depending on the type of glomerular kidney assessed by histopathology, it was found that in Glomerular Non-proliferative Kidney: 12 (10.61%) patients are of minimal Change disease (MCD), 9 (7.96%) Focal Segmental Glomerulosclerosis (FSGS), 25 (22.12%) Membrane glomerulonephritis (MGN). In proliferative glomerular nephrosis: membrane-hyperplastic glomerular nephrosis - 13 (11.5%), IgA nephropathy -13 (11.5%), mesangial proliferative glomerular nephrosis -14 (12.39%), Focal Segmental Proliferative Glomerulonephtis-14(14.2%), 2 (1.8%) Rapidly Progressive glomerulonephritis (RPGN and chronic sclerosing glomerulonephritis is -11 (9.7%). Conclusion: Our study to determine the pattern of primary glomerulonephritis found nearly similar results in the South Asian populations, as has been shown by various studies in the region. We have some differences in research in the West, Europe, America, and the Middle East, which may be due to environmental, genetic, racial, social and economic differences. Key words: primary glomerulonephritis, renal bipolarity, histological typing