::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

PROSPECTIVE OBSERVATIONAL STUDY ON UTILIZATION OF ANTIEPILEPTIC DRUGS IN EPILEPTIC AND NON-EPILEPTIC CONDITIONS IN A TERTIARY CARE TEACHING HOSPITAL

AUTHORS:

Dr. MD Ateeq-Ur-Rahman, Mubeena Fatima, Noor-Us-Sabah Juveria, Manal Shakeel Ahmed, Asna Amreen

ABSTRACT:

Background: In recent years many AEDs are been prescribed for indications other than epilepsy. DUE determines the quality, standards of prescribing therapy in accordance with the guidelines and to assess its prescribing trends in various epileptic and non-epileptic populations. Pharmaco-resistant epilepsy has become major medical trouble with 5 fold higher mortality rate and awaits satisfactory management. Our study will be considered as an update that builds on & expands the findings of previous studies. Materials & Methods: Evaluation of 200 prescriptions of epileptic & non-epileptic patients with an emphasis on Drug refractory epilepsy presenting to the Department of Neurology, Osmania General Hospital, Hyderabad. Aims & Objectives: To assess the AED utilization pattern in epileptic & non-epileptic conditions. Results: The probability of patients receiving Anti-epileptic Drug therapy for epilepsy was higher (55.5%) than non-epileptic patients (45%). In epileptic patients, slight female preponderance was observed over males. The dominant age group of the study was 20-40 years and the highest numbers of AEDs were prescribed for GTCS (45.94%). Polytherapy was most commonly employed. A progressive decrease in Carbamazepine use and a gradual rise of levetiracetam use was observed. 3rd generation AEDs top the list in non-epileptic conditions. Statistical analysis comparing Monotherapy with combination therapy of gabapentin & pregabalin, we found significant p-value in different non- epileptic conditions. In our study, we found a total of 8 patients (7.20%) with drug-refractory epilepsy, of which 75% had GTCS. Conclusion: Our study highlights the relevant differences in the utilization of older and newer generation AED. Phenytoin, the conventional AED was common in epileptic patients, while 3rd generation narrow-spectrum AEDS like gabapentin & pregabalin for non-epileptic conditions, most commonly in neuropathic pain. Keywords: Anti-epileptic drugs, Drug-resistant epilepsy, Epilepsy, Non-epileptic conditions, Refractory epilepsy, Pregabalin, Gabapentin.