- CODEN : IAJPBB
- issn 2349-7750
TITLE:
RISK FACTORS & CLINICO-BACTERIOLOGICAL PROFILE OF EARLY ONSET NEONATAL SEPSIS
AUTHORS:
Dr Rushna Haseeb, Dr Moaz Ahmar, Dr Mahzaib Babar
ABSTRACT:
Aim: To investigate the risk factors and the clinical-bacteriological profile of early neonatal sepsis in the neonatal intensive care unit. Study Design: observational / descriptive. Place and duration: In the Pediatric Unit-II of Jinnah Hospital Lahore for one-year duration from April 2019 to April 2020. Material and Methods: Relevant data on maternal risk factors was collected by collecting maternal histories and consulting their case files. All infants who develop clinical signs of sepsis that are culture positive or confirmed by at least 2 laboratory parameters within 7 days of birth have been diagnosed with early onset neonatal sepsis (EONS). Data was analyzed using SPSS version 19. Results: Out of 2,620 live births, 82 newborns were diagnosed with EONS (incidence 31.3 / 1,000 live births), the ratio of women to men was 1: 1.5, and the maximum number of cases was in the 0-3 days age group (54.8%). Most of the cases (60.9%) were from the lower socioeconomic group. Among newborns with EONS, 48.8% and 75.6% had low birth weight and premature babies, respectively. Culturally confirmed cases accounted for only 17.1%. It should be noted that of those developing EONS, 71.9% were neonates judged to be at risk of sepsis due to the presence of maternal and neonatal risk factors. The most important perinatal risk factors were prolonged rupture of membranes and foul-smelling liquid. The most important comorbidities were hyperbilirubinemia (26.8%), metabolic acidosis (19.5%), and DIC (14.6%). In this study, the mortality rate was 7.3%. Klebsiella pneumoniae and Pseudomonas were the most common causative organisms found in positive cultures (42.8%). Conclusion: Detecting risk factors and knowing the clinical-bacteriological profile of EONS can lead to early diagnosis and rapid therapeutic interventions that minimize neonatal mortality and morbidity. Key words: early-onset neonatal sepsis, risk factors, low birth weight, premature baby
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