Abhale Swapnali S., Loharkar Harshal S., Rakibe Vaishali D.
Co crystal is an important and useful product in the pharmaceutical industry. In this paper included the main information about co-crystals. Polymorphism is one of the phenomena to related co-crystal which is beneficial crystallization. Crystal is prepared by various methods at the commercial level like as grinding, slurry method, Hot melt extrusion, Antisolvent method, supercritical fluid technology, Spray drying technique are used for the preparation of co-crystal. Before applying the co-crystals in any production to check for characterizing like solubility, maximum wavelength, stability, crystallographic method, different scanning calorimetry, thermal analysis, spectroscopy, scanning electron microscopy, melting point. The co-crystals are applying in the pharmaceutical industry for improving such different parameter stability, solubility, dissolution rate, hygroscopicity, or mechanical property. Earlier day regulatory market is responding to the growth of a product or needs to approval to product to in market like USFDA, EMA regulatory agencies. Now a day new advancement comes in co-crystallization production or to develop their easy application they are multi-drug nanocrystal, polymorphism, salt cocrystal, quick co former screening, etc. The main purpose of the article to know about co-crystallization and their related factors. Keywords: crystallization, polymorphism, method of preparation, characteristics, and properties of the co-crystal, regulatory aspect of co-crystal, new advancement