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A CORRELATION BETWEEN INFERTILITY AND THYROID AUTO-ANTIBODIES IN WOMEN OF REPRODUCTIVE AGE GROUP: A RETROSPECTIVE CROSS-SECTIONAL STUDY

Dr. Nazima Khatun, Dr. Ashish Raj Bista, Dr. Gantuya Tserenpil, Dr. Riwaj Pyakurel, Dr. Meklit Tesfaye Gebre, Dr. Saima Naz Shaikh, 7Dr. Nilay Bhatt

Objective:This study intends to ascertain the prevalence of thyroid auto-antibodies in reproductive age group female patients with infertility referred to our centre in Bengaluru. Materials and Methods:Our retrospective cross-sectional study was carried out at MVJ Medical College and Research Hospital, Bengaluru, India from June 2015 to May 2019. A total of 1392 female infertile women was included in the study population and were assessed for the presence of thyroid auto-antibodies (anti-TPO and anti-TG). Results:We detected the presence of either anti-TPO or anti-TG antibodies in 287 patients (20.7%). The mean age of patients with positive thyroid auto-antibodies is 28.4 ± 0.84 years, while it is noted to be slightly higher among those with negative lab results with 29.7 ± 0.44 (p-value= 0.72). It has been found that, 192 (66.8%) patients tested positive for Anti-TPO antibodies and 95 (33.2%) of them for Anti-TG antibodies. Conclusion: As the prevalence of thyroid auto-antibodies are found to be high among infertile and sub-fertile women, It is therefore suggested to screen for the elevated titres of thyroid auto-antibodies to minimize the adverse pregnancy outcomes. Keywords: Infertility, Autoimmune thyroid disease (AITD), thyroid auto-antibodies, Hypothyroidism, Hyperthyroidism, Subfertility

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