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ANALYSIS OF THERAPEUTIC EFFECTS OF LOW DOSE UNITREXATE IN NEUROPATHOLOGICAL DISORDERS IN PAKISTAN

Dr Samina Fida, Dr Javed Iqbal

Introduction: There are many biochemical and inflammatory reactions which develop due to the effect of secondary spinal cord injury (SCI) are also called secondary cord damage creates the edema during acute stage. Objectives of the study: Based on all facts this study was designed to investigate the comparison of effects of low-dose unitrexate in neuropathological disorders in Pakistan. Material and methods: This cross sectional study was performed in CMH Lahore during January 2019 to July 2019. This study was done according to the ethical committee of university and hospitals and all the protocols were reviewed by the committee. A total of 100 patients were selected for study who was suffering from any neurological disorder and use these type of drugs. The study was further divided into further groups. Results: The variations between the mean values of MPO levels were significant according to the ANOVA and t-test. There were significant difference between control groups and treated groups. The data shows that the group of patients which was treated with both MTX and MP as a combine effect shows more close values to the control. But the separate effect shows somehow different values as compared to control. Conclusion: Low dose unitrexate is more effective as compared to methylprednisolone in neurological disorders. Key words: Dose, Injury, Unitrexate

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