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STRATEGIES FOR THE USE OF INSULIN SENSITIZING DRUGS TO TREAT INFERTILITY IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Dr Afsah Farooq,Dr Mashal Nayyab Tariq,Dr Rida Fatima.

To establish the features of biochemical and clinical in PCOS (polycystic ovary syndrome) individuals using IR insulin resistance; and also to assess the insulin sensitizing drug role (in the shape of metformin as a drug) in the patients of infertile IR PCOS in regards to either reproductive or metabolic functionality. The total number of patients is 55 and in these 55 PCOS women, with a preliminary ailment of infertility along with other demonstrations consist of hirsutism, obesity, as well as acanthosis nigricans (AN). In accordance with the ratio of fasting glucose/insulin (G/I), these 55 patients have been further categorized into two groups; the first one is Group I: IR PCOS and the second one is Group II: non-IR PCOS. Both groups' patients have been provided Clomiphene citrate (CC) for five days starting from the second day of the entire duration for six months. Similarly, Group I was further categorized in line with medication protocol into Group Ia which was given metformin every day along with (CC) and Group Ib only offered CC. BMI, Ferriman-Gallwey score as well as (G/I) were determined. Fasting insulin (I) and Fasting glucose (G), luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P), testosterone (T), total cholesterol (TC) and triglyceride (TG) have also been assessed. The medical, as well as biochemical variables, have been examined at first and also at the completion of treatment. Sixty-two percent, as 34 of the 55 patients having PCOS experienced IR. Hirsutism, obesity, as well as AN, have been frequent relationship as part of group I. In group I, LH, LH/FSH as well as T have been notably reduced as compared with another group (P> 0.05). In group Ia, nearly all post-treatment variables have been importantly enhanced in comparison with group Ib with the ratio of (P >0.05). IR-PCOS patients tend to be more inclined that they are overweight, hirsute and in addition have AN. They are additionally more resistant against ovulation induction along with CC. They usually have reduced levels of LH, LH/FSH and T. Metformin boost the reaction to ovulation induction with CC and the rate of pregnancy IR-PCOS. Moreover, it seems that metformin might be helpful while enhancing the metabolic variables linked with IR syndrome to ensure that it may decelerate or protect against the prolonged challenges with this disorder. Keywords: PCOS; insulin sensitizing drugs; insulin resistance;

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