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GENETIC PREDICTORS OF THE CHRONIC HEART FAILURE DEVELOPMENT AND PROGRESSION: THE ROLE OF POLYMORPHIC GENES

Tokmachev R.E., Kravchenko A.Ya., Chernik T.A., Mekhantieva L.E., Tokmachev E.V., Saurina O.S., Ovsyannikov E.S., Popov A.A., Simenskaia E.M.

According to the results of epidemiological studies conducted in the last decade, achievements in the treatment of cardiovascular diseases are noted, but despite this there is a continuous increase in chronic heart failure (CHF), primarily due to the prevalence of etiological causes, a significant increase in the average life expectancy of patients, “escape phenomena” with the prescribing of β-blockers (BB) and blockers of the renin-angiotensin-aldosterone system (RAAS) at the outpatient stage. Studying the contribution of various genes to predicting the risk of occurrence, the nature of the course, and choosing the optimal therapy for a stable course of CHF is an relevant scientific and clinical task. The article provides an overview of the most ambitious clinical studies available to date, both foreign and domestic, which allow us to conclude about the role of genetic factors in the development and progression of CHF. The main gene polymorphisms that are components of the sympathoadrenal (CAS) and renin-angiotensin-aldesterone systems (RAAS) are considered, which is associated with their leading role in the pathogenesis of not only basic diseases, but also CHF itself. The studies presented in the article confirm the multifactorial nature of CHF, and demonstrate a certain relationship between gene polymorphism with clinical manifestations, response to therapy, mortality, and confirm the need for further study of the genetic mechanisms of development and the clinical course of CHF. Key words: CHF, polymorphic genes, RAAS, CAS, AGT gene, ADRB gene polymorphism.

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