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ASSESSMENT OF EFFICACY OF INSULIN SENSITIZER THERAPY IN WOMEN WITH PCOS TO REDUCE THE INFERTILITY RISK

Kommalapati Ambika, Kavuri Naga Swathi Sree, Jonnala Divya, N. Prabhavathi, P. Sharmila Nirojini

Polycystic Ovary Syndrome (PCOS) is emerging endocrine disorder during Reproductive years. Ovulatory dysfunction in these women leads to increased risk of infertility and adverse obstetric outcomes. This study is intended to assess the efficacy of Insulin sensitizer to reduce infertility risk in PCOS patients. Study design is Prospective observational study, study site at Department of Gynaecology and Obstetrics, Government General Hospital, Guntur. Study period: 1st September 2018 to 28th February 2019. Present study shows results, out of total subjects 60% of subjects have stress and 45% of subjects have obesity as a promoting factor and only few as a family history of PCOS. Among 190 study sample, 101 subjects are taking different insulin sensitizer in that 66 subjects taking myocyst M (Myo-inositol and Metformin) as a insulin sensitizer and remaining 35 taking Metformin, about pregnancy status 146 are married and 44 are unmarried in that 146 married subjects 59 attained pregnancy during our study period, by correlating the pregnancy status with insulin sensitizer use out of 59 pregnant women 55 subjects were taken insulin sensitizer therapy and remaining 4 were not taken insulin sensitizer therapy, it clearly states that there is an association between insulin sensitizer usage and pregnancy outcome these can be stated by doing chi-square test which gives the significant value p< 0.0001****. Finally conclude that major risk factor for PCOD were stress and obesity. In that moderate stress subjects were more, most of the risk factors were modifiable. Women with PCOS suffered from infertility problem, by the use of insulin sensitizer infertility risk was reduced, mainly ≥6months duration use of myocyst M (Myo-inositol and Metformin) shows positive pregnancy outcome. Key Words: promoting factors, Pregnancy outcome, insulin sensitizer therapy, Metformin, Myocyst-M

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