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A COMPARISON OF TWO PROTOCOLS OF INTRAVAGINAL MISOPROSTOL FOR SECOND TRIMESTRER MEDICAL TERMINATION OF PREGNANCY

Dr Bilal Ahmed, Dr Fariha Saher, Dr Muhammad Ahmad Javed Alvi

Objective: To look at the adequacy and reaction profiles of two distinctive measurement conventions of intravaginal misoprostol. Material and Methods: This randomized control trial was held at Mayo Hospital, Lahore from May 2018 to February 2019. An aggregate of 128 women, matured 18-40 years, made arrangements for second-trimester pregnancy end, were arbitrarily distributed to two groups of 64 each. Group – I ladies got vaginal misoprostol 400ug three hourly for a limit of 8 dosages in 24 hours. Ladies in group II got vaginal misoprostol 400ug six hourly for a limit of four portions in 24 hours. On the off chance that premature birth did not happen in 24 hours, similar regimens were rehashed. Without successful fetus removal in 48 hours, the misoprostol organization was deserted for careful enlistment. Results: The middle enlistment to fetus removal interim in the group – I (14.4 hours) was shorter than group – II (18.2) (p< 0.001). The recurrence of fever was increasingly normal in the group – I (p = 0.01). The pregnancy-related indications diminished in the two groups after misoprostol and abatement in bosom delicacy was most stamped a few hours after the organization. Misoprostol initiated fever was seen in any event five hours after organization in up to 37.5% ladies, this pinnacle being somewhat higher and happening prior in the group – I than in group – II. Lower stomach agony crested following three to four hours in the group – I and following five to six hours in the group – II, with no huge distinction in torment force or pain-relieving necessities. Other regular reactions were loose bowels pursued by queasiness and spewing in both the groups. Conclusion: Protocol of 400ug misoprostol regulated 6 hourly/24 hours is increasingly compelling in decreasing acceptance – fetus removal interim and instigating fruitful premature birth inside 48 hours with no real increment in reactions. Keywords: Reaction Profiles, Measurements, Intravaginal, Misoprostol, Regimens, Reoccurrence and Interim Removal.

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