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SECOND-LINE TREATMENT FOR HELICOBACTER PYLORI: SYSTEMATIC REVIEW STUDY

Dr. Muhammad Jazib Khilji, Dr. Ramsha Ghias, Dr. Muhammad Usman Noor

Background: Multiple Helicobacter pylori second-line schedules have been described as potentially useful. It remains unclear, however, which are the best combinations, and which features of second-line treatments are related to better cure rates. The aim of this study was to determine that second-line treatments achieved excellent (>90%) cure rates by performing a systematic review Methods: A systematic review for studies evaluating second-line Helicobacter pylori treatment was carried out in multiple databases. Results: The systematic review identified 115 eligible studies, including 203 evaluable treatment arms. The results were extremely heterogeneous, with 61 treatment arms (30%) achieving optimal (>90%) cure rates. Conclusion: Second-line Helicobacter pylori treatments achieving>90% cure rates are extremely heterogeneous. Quadruple therapy and 14-day treatments seem better than triple therapies and 7-day ones. No single characteristic of the treatments was related to excellent cure rates.

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