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COMBINATORIAL EFFECTS OF METHANOL EXTRACT OF IMPERATA CYLINDRICA AND JATHROPHA CURCAS ROOTS ON TESTOSTERONE-INDUCED BENIGN PROSTATE HYPERPLASIA (BPH) IN MALE ALBINO RATS

Ganyam, M. M, Arazu A. V,*Amadi Ben C, Itepu Victor E, Ugwuoke K.C, Samuel C.

This study was aimed at evaluating the effects of methanol extract of Imperata cylindrica and Jathropha curcas roots on testosterone-induced benign prostate hyperplasia (BPH) in male albino rats. A total of 27 male albino rats were divided into 9 Groups of 3 rats each. BPH was induced using 25 mg/kg b.w of testosterone propionate subcutaneously for 28 days in all the groups with exception of the normal control group, followed by treatment immediately, for 14 days. Biochemical assays such as liver function test (ALT, AST and ALP), kidney function test (Urea and Creatinine), antioxidant (SOD and CAT), MDA, testosterone, zinc concentration and prostate specific antigen (PSA) levels were analyzed using standard procedures. Prostate weight (prostate/body weight ratio) and percentage inhibition of prostate weights, were also calculated. The result obtained revealed a decrease in mean body weight from day 1 to day 14. The results showed a non-significant (p > 0.05) difference in the level of liver enzymes. The Malondialdehyde (MDA) concentrations significantly (p < 0.05) decreased was observed within the groups. A noticeable change was also observed in antioxidants enzymes. The prostate weight significantly decreased when decrease in prostatic index. These results suggest that methanol extract of Jathropha curcas roots and its combination with Imperata cylindrical may be effectively used in the management of BPH. Key words: Imperata cylindrical roots, Jathropha curcas roots, testosterone and benign prostate hyperplasia (BPH)

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