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СLINICAL AND LABORATORY PECULIARITIES IN PATIENTS WITH COPD AND ASTHMA DEPENDING ON BMI

Tribuntseva L.V., Budnevsky A.V., Avdeev S.N., Tokmachev R.E., Ovsyannikov E.S.

The purpose of the study was to assess the effect of body weight on the course of COPD and asthma. Material and Methods: The clinical phase of the study was conducted on 113 patients with asthma and 264 patients with COPD. The patients were divided into 3 groups within their nosology depending on their BMI: with normal body weight (BMI: 18.5-24.99), overweight (BMI: 25-29.99) and obesity (BMI: 30 or more). At the first stage of the study, an individual registration card was filled out for each patient. The symptoms of asthms and COPD were objectified by using a 10-point visual analogue scale. To assess the severity of shortness of breath, a 4-point mMRC scale was used. The severity of symptoms of COPD and the impact of the disease on the daily activities of patients was assessed using the COPD Assessment Test. To assess the symptoms of COPD over the past week, a clinical questionnaire for COPD has been used - The Chronic obstructive pulmonary disease Control Questionnaire. To assess the degree of asthma control, an Asthma Control Test was used. The “Quality of Life for Asthma Patients” was used to assess the quality of life of patients with asthma, and for patients with COPD - Short Form Medical Outcomes Study 36. All patients underwent spirometry. The study of specific markers in blood serum was performed; in this research work have been analysed levels of leptin, adiponectin, the degree of total oxidative damage (TOD), the total antioxidant status (TOS), IL-4, IL-6, TNF-α, neuropeptide Y. All received data were compared with the severity of clinical symptoms. The data were processed statistically using standard computer programs. The data obtained allow us to conclude that obesity as a source of chronic systemic inflammation is a predictor of the adverse course of asthma and COPD. To numerically determine the effect of obesity on these pulmonological pathologies, the following serum indices can be used: leptin, resistin, TNF-α. In addition, for asthma, in particular, neuropetid Y, the total oxidative damage and the total antioxidant status are promising markers. Key words: asthma, COPD, BMI, neuropeptide Y.

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