::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

LIPID CHANGES IN PATIENTS WITH TYPE II DIABETES MELLITUS AND THEIR RELATION WITH MICRO AND MACRO VASCULAR COMPLICATIONS

AUTHORS:

Dr Muhammad Asif Saleem, Dr Muhammad Umair Afzal, Dr Batool Riasat Ali

ABSTRACT:

Background: Patients with type II diabetes may develop complications over a longer period of time. These complications may be related to changes in lipid markers. Aims: To identify changes in lipid metabolism in type 2 diabetes in the context of glycemic status, its relative impact on macro and microvascular events, and the effect of insulin therapy on lipid indexes. Place and Duration: In the Medicine Unit-II of Jinnah Hospital Lahore for one-year duration from March 2019 to March 2020. Methods and material: 158 patients with type II diabetes and 30 patients without coincidental illness were selected as a control group for the study. Total cholesterol, triglycerides, HDL-C, Cholesterol / HDL-C ratio, and atherogenic index (AI) were estimated, and the data were statistically analyzed. Results: The atherogenic index and CHOL / HDL-C levels were significantly higher in diabetics than in the control group. It was also found that both indices were lowered in patients treated with insulin. The AI of patients with complications was also significantly higher than those of patients without complications; however, CHOL / HDL-C was not significantly different. Therefore, using the best AI cut-off values can be used as a better complication rate than the CHOL / HDL-C ratio. Conclusion: AI may be used to indicate the presence of increased cardiovascular risk in patients with DM type II and as a guide to an aggressive therapeutic approach. Key words: type II diabetes mellitus, lipid indices, atherosclerotic index, micro and macrovascular complications.