- CODEN : IAJPBB
- issn 2349-7750
TITLE:
EFFICACY OF FIRST DOSE OF NITAZOXANIDE IN MANAGEMENT OF ROTAVIRUS DIARRHEA IN CHILDREN
AUTHORS:
Urwa Yaqoob, Rimsha Yousaf, Haafizah Anam Saeed
ABSTRACT:
Rotavirus is a leading cause of morbidity and mortality in children younger than 5 years. This study was planned to record mean duration of rotavirus diarrhea in children after administration of first dose of nitazoxanide as this drug is cost effective but no local data is available evaluating mean duration of diarrhea after first dose of Nitazoxanide in children with rota virus, while the previous studies were conducted on smaller sample size. Objective: To determine the mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide. Study Design: Descriptive Case study. The calculated sample size is 175, with d=1, 95% confidence level taking expected mean duration of diarrhea after first dose of administration of Nitazoxanide i.e. 31.0+6.87 hours Setting: The study was conducted in Department of Pediatric Medicine, Children Hospital, Faisalabad. Duration of study: Six month from the date of approval of synopsis from board of study (July 2019 to Dec 2019) Methodology: All 175 patients fulfilling the inclusion/exclusion criteria were enrolled in the study. An informed consent to include their data with the assurance of confidentiality was obtained from their parents. All study cases were administered by the nursing staff as (200 mg nitazoxanide) twice a day for 3 days in patients 4–5 years of age, (100 mg nitazoxanide) twice a day in patients 12–47 months of age, and (7•5 mg/kg nitazoxanide) twice a day in patients younger than 12 months. In addition to the study education, all patients were receiving routine care including fluid replacement therapy and nutritional and metabolic management of diarrhoea. The nursing staff followed the children for every 12 hours till the normal formed stools. All this information was recorded on a pre-designed proforma. Duration of diarrhea was recorded as per operational definitions. Results: In our study, out of 175 cases, 58.86%(n=103) were between 2-36 months of age while 41.14%(n=72) were between 37-60 months of age, mean+sd was calculated as 35.06+13.34 months, 44%(n=77) were male and 56%(n=98) were females, mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide was recorded as 32.85+2.32 hours. Conclusion: We concluded that the mean duration of rotavirus diarrhea in children after administration of first dose of Nitazoxanide is not more than 1.5 days and it is suitable in our population for the management of rotavirus diarrhea. Keywords: Children, rotavirus diarrhea, Nitazoxanide, duration of diarrhea
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