B. Manjula, V. Rama Mohan Gupta, K. B. Chandra Sekhar
In the present study, an attempt was made to develop the transdermal drug delivery systems of Fluvastatin sodium using Liposomes incorporated in a gel, which will control the release of drug, increasing the bioavailability of the drug and thus decreasing the dosing frequency of the drug. It was designed by encapsulating the drug in various Liposomal formulations composed of various ratios of Soya Lecithin: Span 80 or Tween 80 or sodium deoxycholate. The Liposomes were prepared by rotary evaporation sonication method. Lipid: surfactant ratio of 90:10 is found to be more effective when compared to other ratios. Experimental results of the present study showed that deformable lipid vesicles improve the transdermal delivery, prolong the release, and improve the site specificity of the Fluvastatin sodium. The drug diffusion studies showed that the prepared liposome vesicles followed zero order kinetics and mechanism of drug diffusion followed peppas model. Key Words: Liposomes, Anti-hyperlipidemic, Controlled release, Lipid, Surfactant.