::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY TO DETERMINE THE INCIDENCE OF CUTANEOUS CHANGES AMONG PATIENTS ON ORAL STEROIDS

AUTHORS:

Dr. Mahzaib Babar, Dr. Moaz Ahmar, Dr. Rushna Haseeb

ABSTRACT:

Background: Corticosteroids revolutionized the treatment of many skin diseases in the fifth and sixth decades of the last century. They have anti-inflammatory, vasoconstrictive, anti-proliferative and immunosuppressive effects. Aim: The aim of the study was to determine the frequency of skin lesions in patients taking oral steroids and to understand the pattern of these changes in our population. Material and methods: The study was conducted in the dermatology department of the Jinnah Hospital Lahore for six-months duration from October 2019 to March 2020. 204 patients who met the inclusion criteria completed the study. All patients were taking 60-80 mg of oral steroids for a minimum of 2 weeks. The results were recorded on the preformed pro forma. All relevant investigations were also carried out. Results: Multiple cutaneous infections were the most common side effect seen in 45 patients (22%, p>0.10). Moon face was seen in 39 patients (19%, p0.08). Atrophic changes occurred in 45 patients (22.5%, p> 0.47). Other findings seen in our patients were acneiform eruptions in 18 patients (8.7%, p>0.013). Conclusion: Oral steroid therapy is associated with significant cutaneous side effects that depend on the dose and duration of therapy. Bacterial infections remain the most common side effect. Keywords: oral steroids, infections, atrophy, moon face, buffalo hump.