- CODEN : IAJPBB
- issn 2349-7750
TITLE:
SERRATIOPEPTIDASE LOADED NANOCOCHLEATE: NOVEL APPROACH FOR TRANSDERMAL DRUG DELIVERY SYATEM
AUTHORS:
Dr. Meghana R. Babar, Naveena. V. Vengala, Juhi Singh,
ABSTRACT:
Objective: Nanoochleates are tubular or cockle shaped structures derived from liposomes. Although investigated for several applications to be administered by oral and parenteral route, the potential of cochleates in topical drug delivery remains unexplored. The present study is a comprehensive report aimed at ascertaining the role of cochleates in topical delivery of drugs.Methods involved development and evaluation of lipoid S 75 based nanocochleate formulation of serratiopeptidase. A 23 factorial design was utilized to optimize nanocochleate formulation and to study effect of lipoid S 75, cholesterol and calcium chloride on percent entrapment efficiency and particle size of nanocochleate. Nanocochleates were also characterized by FTIR and DSC. The anti-inflammatory activity and stability of SRP nanocochleates was investigated. The Results of Nanocochleates were prepared by using 749.98 mg of lipoid S 75, 250 mg of cholesterol and 15 mM of CaCl2 having a particle size 231.4 μm and entrapment efficiency of 80.12. The variables of the 23 factorial design significantly affected the percent entrapment efficiency and nanocochleate size. Carbopol 940 was chosen for gel preparation because of its bio-adhesive property and it is known to be retained for longer time at the site of administration. For determining anti-inflammatory activity SRP loaded nanocochleate gel was subjected for in vivo study. SRP loaded nanocochleate gel showed greater percent edema inhibition then the plain SRP gel and comparable with diclofenac gel (VoveranEmulgel). Nevertheless, the prepared nanocochleate formulations possessed stability profile similar to liposomal counterpart. Keywords: Serratiopeptidase, Nanocochleate, Anti- inflammatory, Factorial design, Liposome
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NLM ID:101711216 [Serial]
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