::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

SERUM CALCIUM AND ALKALINE PHOSPHATASE LEVELS IN PATIENTS TAKING ANTIEPILEPTIC DRUGS

AUTHORS:

Muhammad Tayyab Zia, Omaila Ikram, Nimra Ghazal

ABSTRACT:

Millions of people in the world-wide are affected by a chronic condition of epilepsy. In world more or less 50 million people have a medical condition of this syndrome. In order to treat epileptic patient antiepileptic drugs are acting as a chief support. It is observed from findings that constant use of antiepileptic drugs are coupled with reduced bone mineral density and deformities in bone metabolism. Patients receiving antiepileptic drugs are more prone to the diseases of bone. Numerous biochemical irregularities of bone metabolism that consist of hypocalcemia, hypophosphatemia, elevated alkaline phosphatase level, low vitamin D levels have been associated with the use of antiepileptic drug. This research will assist to establish the undesirable influences of these drugs on bones and regarding calcium and vitamin D supplements to be provided during the treatment with antiepileptic drugs. OBJECTIVE: To determine frequency of hypocalcemia and elevated alkaline phosphatase levels in patients taking antiepileptic drugs. STUDY DESIGN: Descriptive cross sectional SETTING: The study was conducted in Mayo Hospital, Lahore. DURATION OF STUDY: Six month from the date of approval of synopsis from board of study March 10, 2017 till Sep 10, 2017 METHODLOGY: In this study a total sample size was 95 patients Patient full summary including name, age, sex, hospital number, details of drugs and date of inclusion in study was noted down blood sample of 3 ml was taken and sent to laboratory for measuring serum levels of calcium and alkaline phosphatase. Test was performed in selectra pro XL machine using photometric method. In the pre-designed Performa, all statistics was entered. RESULTS: Our study shows that mean age was 7 years with SD ± 2.713. Fifty five percent children were male while 45% children were female. Sixty two percent children had Hypocalcaemia and seventy five percent children had raised alkaline phosphatase. CONCLUSION: Our study concludes that 62% of epileptic children had hypocalcemia and 80% had raised alkaline phosphatase levels. KEYWORDS: hypocalcemia, alkaline phosphatase levels, antiepileptic drugs.