::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

IMPACTS OF SUPPLEMENTATION OF LOW DOSE FOLIC ACID AND LOW DOSE HRT AND INFLUENCE OF COMBINED TREATMENT OF HRT AND FOLIC ACID ON THE LEVEL OF PLASMA OF HOMOCYSTEINE IN POST-MENOPAUSAL FEMALES

AUTHORS:

Dr Nazakat, Dr Sundas Fatima, Dr Saulat Shabbir

ABSTRACT:

Objective: To assess the impacts of HRT (Hormone Replacement Therapy) and supplementation of folic acid level of HCY (Homocysteine) in post-menopausal females. Methodology: This randomized research work was carried out on 66 menopausal females for two years visiting the Avicenna Hospital Lahore from March 2018 to May 2020. We randomly separated the patients into 4 separate groups. Before examining the plasma level of folate, Albumin, fasting plasma level and total protein, measurement of HCY was performed. The subjects of the 1st groups took 5.0 mg folic acid daily. The patients of 2nd groups received 0/625mg oral conjugated estragon as well as med Roxy progesterone acetate 2.0/5.0 mg daily. The patients of the 3rd group took combination of HRT and folic acid and the patients of the 4th group received the placebo. We measured the fasting plasma Homocysteine after four weeks. Results: There was significant decrease in the plasma HCY level significantly in the patients of Group-1, Group-2 and Group-3 (P< 0/05) after completion of treatment. We found much significant difference between the patients of Group-1, Group-3 (P=0/026) and Group-1, Group-4 (P=0/005) for plasma Homocysteine level. Conclusion: Treatment with folic acid and HRT can decrease the plasma level of Homocysteine. Combined treatment from both folic acid and HRT is highly effectual as compared to the treatment through supplementation of folic acid and HRT in the decrease of Hyperhomocysteinemia. Keywords: Folic Acid, Hormone Replacement Therapy, Plasma, Treatment, Supplementation, Menopausal Females.