Dr Anam Sadia, Dr Waqas Ahmed, Dr Shawana Saeed
Celiac sprue is another name of celiac disease. It is a severe inflammatory disorder of small intestine, which is caused by ingestion of gluten items in susceptible people. This disease is multifactorial and includes environmental as well as genetic factors. Gluten falls under enviornemntal factors and genetic predisposition is considered as the major complex histocompatibility region. Celiac disease is not rare anymore and has 1% of global prevalence. The reason it is not highly recognized is that most of the people do not have classic GIT symptoms, but they do show some nutritional deficiency or sometimes no symptoms at all. Here, in this review paper recent data encapsulating epidemiology, clinical presentation and therapeutic management of celiac disease is presented.