::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A COMPARATIVE STUDY ON THE DIAGNOSTIC PRECISION RATE OF ULTRASONOGRAPHY AND FINE-NEEDLE-ASPIRATION CYTOLOGY FOR THE PREDICTION OF BENIGN THYROID LESIONS

AUTHORS:

Dr Maria Azam, Dr Iram Sarwar, Muhammad Hasnat Maqsood

ABSTRACT:

Objective: The abnormal development of the thyroid glands is thyroid nodules that is the cause of formation of mass inside the thyroid gland. TNs (Thyroid Nodules) are much common and significance lies in the requirement to exclude the thyroid cancer. The objective of this research work was to assess the diagnostic preciseness of the ultrasonography in comparison with the FNA (Fine Needle Aspiration) cytology to differentiate the benign thyroid abrasions from malignant thyroid lesions. Methodology: 133 patients were present with thyroid abrasions. All the patients had to undergo ultrasonography and Fine-needle-aspiration cytology. We compared the results of both examinations. Results: The average age of the patients of this research work was 41.20±15.0 years and 85.0% (n: 113) patients were females. There were benign thyroid abrasions in 94.70% (n: 126) patients and thyroid lesions were malignant in 5.30% (n: 9) patients. Among 124 patients with benign thyroid abrasions diagnosed with ultrasonography, 98.38% (n: 122) patients got confirm diagnosis with use of FNA cytology and there was presence of malignancy in only1.60% (n: 2) patients. Among total 9 patients present with malignant thyroid lesions as diagnosed with US, Fine-needle-aspiration cytology confirmed 5 patients with malignancy and 4 patients were present with benign thyroid abrasions. US identified the BTL (Benign Thyroid Lesions) with sensitivity, specificity, PPV (Positive Predictive Value) and NPV (Negative Predictive Value) of 98.380%, 71.420%, 98.380%, and 55.550% correspondingly. The finding showed the positivitybetween diagnosis of BTL by US and confirmed diagnosis with the use of Fine-needle-aspiration cytology (P<0.0010). Conclusion: A much valuable tool to differentiate the BTL from the MTL is B-mode ultrasonography. It helps in the prediction of the benign nature of thyroid abrasions with excellent preciseness in diagnosis. Keywords: Benign Thyroid Lesions, Ultrasonography, Fine-Needle-Aspiration, Comparison, Thyroid Nodules