::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ANTIOXIDANTS AS A BIOMARKER OF CARDIOVASCULAR RISK IN YOUNG PEOPLE

AUTHORS:

Dr. Hafiz Muhammad Junaid, Dr. Muhammad Bilal Liaqat, Dr. Samia Munir

ABSTRACT:

Introduction: Cardiovascular diseases (CVDs) are a group of diseases that share the principal risk factors and often the aetiology. Aims and objectives: The main objective of the study is to analyze the level of antioxidants as a biomarker of cardiovascular risk in young people. Material and methods: This cross-sectional study was conducted in Jinnah Hospital, Lahore during October 2018 to January 2109. The data was collected from 100 patients of CVD. The data was collected for the analysis of blood antioxidants level among these patients. Blood sample was drawn for the analysis of serum antioxidants. Blood was centrifuged at 4000 rpm for the separation of serum. Then we find the serum antioxidantslevel by using Ohkawa et al., method. Results: The data was collected from 100 CVD patients. The mean age of the study patients was 54.4±10.6 years. Cigarette smoking was much more common in men than in women (32.6% vs. 0, p<0.001). The serum levels of creatinine, uric acid, and cTAS were significantly higher in men than in women (0.9±0.2 vs. 0.7±0.1, 7.6±2.1 vs. 6.8±2.3, and.0.4±0.0 vs. 0.3±0.1, respectively; p<0.001). Conclusion: It is concluded that age was not a determinant affecting the antioxidative barrier, regardless of the presence of CHD. We showed through a cross-sectional analysis on a large healthy population that a reduced antioxidant capacity is significantly associated with cardiovascular risk factors.