::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EFFECT OF ASPIRIN COMBINED WITH CLOPIDOGREL FOR THE TREATMENT OF THE PATIETNS OF ACUTE MYOCARDIAL INFARCTION WHO UNDERWENT PERCUTANEOUS CORONARY INTERVENTION

AUTHORS:

Dr Irsa Khalid, Dr Maham Arshad, Dr Ayesha Akram

ABSTRACT:

Objective: The purpose of this research was to examine the clinical influences of aspirin in combination with clopidogrel for the patients of AMI (Acute Myocardial Infarction) who underwent PCI (Percutaneous Coronary Intervention). Methodology: Total 132 patients suffering from Acute Myocardial Infarction who got admission in Lahore General Hospital Lahore from May 2019 to June 2020, were separated into observation group (OG) and control group (CG) with sixty-six patients in each group. We gave symptomatic therapy and emergency PCI to the patients of both groups. The patients of CG received aspirin according to conventional treatment prior and after surgery, whereas the patients of OG received the clopidogrel therapy in combination with the treatment provided to the patients of CG. The duration of the treatment was complete four months. We analyzed the clinical effectiveness in the patients of both groups. We also provided the comparison of the indicator of cardiac function, coagulation indicator and prevalence of the adverse side effects prior and after the treatment. Results: We found no thrombosis at infarct site in the patients of both groups in coronary angiography after completion of therapy. Efficacy rates in the patients of OG & CG were 89.40% and 81.80% correspondingly; we found no significant difference in the rates of efficacy of both groups. The rate of occurrence of the re-thrombosis in the patients of OG & CG was 1.50% and 12.10% respectively, which was much lower in the patients of OG as compared to the patients of CG (P<0.050). There was improved cardiac function indicator in the patients of both groups after the treatment, particularly in the OG (P<0.050). We found no important difference in the PT (Prothrombin Time), APTT (Activated PartialThromboplastin Time), PA (Prothrombin Activity) and PAR (Platelet Aggregation Rate) in the patients of both groups prior treatment (P>0.050). We found no significant difference PA &PT prior & after the therapy (P>0.050). There was high difference in PAR &APTT after therapy (P<0.050) and PAR of the patients of OG was much high as compared to the patients of CG (P<0.050). The rate of prevalence of the adverse reactions in the patients of OG was 7.580%, which was not much different from that which was present in the patients of CG as 12.120% (P<0.050). Conclusion: Aspirin in combination with clopidogrel can decrease the prevalence of occurrence of re-thrombosis effectively after PCI and it also has the ability to improve the cardiac function after surgery, the safety of this treatment is also very high. This treatment procedure has important clinical worth. Keywords: Acute Myocardial Infarction, Cardiac, Aspirin, Coronary, Clopidogrel.