::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

PROSPECTS FOR THE USE OF A PRECISION METHOD FOR MANUFACTURING INDIVIDUAL MOUTHGUARDS FOR THE INTRODUCTION OF DOSAGE FORMS INTO THE FOCUS OF ENAMEL DAMAGE IN WEDGE-SHAPED DEFECTS

AUTHORS:

Gazhva S. I.., Yakubova E. Yu., Gazhva Yu. V., Gorbatov R. O., Repina E. A.

ABSTRACT:

In this article, the search for new minimally invasive organ-preserving techniques and methods of their implementation in the treatment of wedge-shaped defects within the enamel is updated. A personalized approach to decision-making related to the treatment of this type of pathology is objectified. Emphasis is placed on the pathogenetic mechanism of this process, taking into account morphofunctional changes in enamel. Changes in the architectonics of the enamel layer of the tooth and its elemental composition were studied and discussed. A hypothesis is made and an option is proposed for creating a drug depot, which is a method of delivering dosage forms to the affected area to create an isolated contact with the hard tissues of the tooth. The purpose of this study was to develop an algorithm for creating precision manufacturing of individual mouthguards for targeted delivery and creation of an isolated depot of dosage forms in the area of enamel damage in a wedge-shaped defect. The scientific basis and principles of the research concept consisted of data obtained on microstructural transformations, changes in the elemental composition of the tooth with a wedge-shaped defect. It is proved that oxygenation increases against the background of a decrease in carbohydrate compounds, there is a decrease in the content of fluorine and sulfur is present in the lesion. The results obtained were the basis for the application of a targeted and personalized algorithm for treating this pathology, using 3D technologies. The results of which can be integrated into the concept of minimally invasive, organ-preserving methods of providing dental care to patients with initial forms of wedge-shaped defects. The study was conducted with the involvement of 38 patients, age and pathology describe, creating a Mat model of the Capa taking into account the volume of the tooth itself and Pro to create a model of the defect within the anatomical shape of the tooth and its location in the dentition mathematical modeling.