::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EFFICACY OF PREOPERATIVE DEXAMETHASONE TO DECREASE NAUSEA AND VOMITING AFTER LAPAROSCOPIC CHOLECYSTECTOMY

AUTHORS:

Dr. Ifrah Tahir, Dr. Sana Abid, Dr. Sheeza Amjad

ABSTRACT:

Laparoscopic cholecystectomy (LC) is one of the most common, popular, and accepted procedures in patients with symptomatic gallstones. Although serious adverse events are rare following laparoscopic cholecystectomy, 50% to 75% of patients experience post-operative nausea or vomiting (PONV). Several randomized controlled trials have shown that a single pre-operative dose of Inj. Dexamethasone is effective in reducing postoperative nausea and vomiting and the need for antiemetics after laparoscopic cholecystectomy because it is freely available, economical, and a single dose does not have any significant side effects, so it should be used more frequently in patients undergoing cholecystectomy laparoscopy. Aim: The objective of the present study is to investigate the outcome in terms of Post-operative nausea and vomiting within 24 hours in patients undergoing Laparoscopic Cholecystectomy receiving preoperative dexamethasone and those not receiving. Place and Duration: This randomized, placebo-controlled, double-blind study will be conducted at the Surgical Unit-II of Sir Ganga Ram Hospital, Lahore for one-year duration from March 2019 to March 2020. Methods: 100 patients; 50 in each group with 80% power of study, 5% significance level and taking percentages of vomiting and nausea in both Dexamethasone and placebo groups, i.e., 14% and 46% respectively. Results and Conclusion: Dexamethasone improves the surgical outcome by reducing disabling symptoms of nausea and vomiting without apparent side effects. However, there is no evidence in reduction of postoperative pain or analgesic requirements in this trial. So preoperative dexamethasone 8mg may be used as a routine in patients two hours before undergoing elective laparoscopic cholecystectomy. Key words: laparoscopic cholecystectomy, dexamethasone, nausea and vomiting.