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TITLE:

ANALYSIS OF EFFECTS OF METHOTREXATE IN COMBINATION WITH METHYLPREDNISOLONE FOR SPINAL CORD INJURY IN PAKISTAN

AUTHORS:

Dr Abdullah khan, Dr Ahmed Hussain, Dr Wazir Zeeshan Haider

ABSTRACT:

Introduction: The incidence of spinal cord injury (SCI) caused by many events, including traffic accidents, mining and construction accidents, seismic and natural disasters, has tended to rise year on year. Objectives of the study: The main objective of the study is to analyze the effects of methotrexate and methylprednisolone in spinal cord injury among local population of Pakistan. Material and methods: This cross-sectional study was conducted in Bahawal Victoria Hospital, Bahawalpur during October 2018 to March 2019. The data was collected from 100 patients of spinal injury. The study was divided into two groups, one was control group and one who was treated with MTX. For biochemical analysis 5cc blood sample was taken from vein and sample were processed with phosphate buffer saline using homogenizer. Blood was centrifuged at 3000rpm for 10 minutes and after that pallet was suspended. Results: The data was collected from 100 patients of SCI. There were significant difference between control groups and treated groups. The swing time in the MP group was significantly shorter than that of the SCI group (P < 0.05) from 2 to 8 weeks post-injury. At 8 weeks post-injury, improvement was significantly enhanced by combined MP and MTX compared with the use of MP alone (P < 0.05). Conclusion: It is concluded that MTX therapy could improve the deficiency of MP treatment alone. MTX, with a flexible administration time, in combination with the traditional SCI treatment drug, MP.

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