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AN EXPERIMENTAL STUDY TO DETERMINE THE EFFECT OF INHALED CORTICOSTEROIDS ON ARTERIAL BLOOD GASES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS

Dr. Ghulam Mustafa, Dr. Ijaz Nazir, Dr. Muhammad Waqas

Pulmonary diseases are of two types, obstructive and restrictive. COPD is chronic obstructive pulmonary disease which is defined as progressively decreased airflow along with inflammation of airways as a result of harmful gases or tobacco smoking. Acute exacerbation of COPD is defined as severely compromised respiratory function, more than usual respiratory variations, which most of the time require change in usual medication and hospital admission and sometimes mechanical ventilation in severe cases. Objective: The purpose of study is to determine the alteration in arterial blood gases values in patients with acute COPD exacerbation after using corticosteroids. Methods: This is quasi experimental study, conducted in a period of 2 months from March to April, 2019 at District hospital Jhang. Results: 45.511.1 years is the mean age of patients. Mean paO2 and PaCO2 are 594.4 mmHg and 57.32.8 mmHg. The difference between values in beginning and end of treatment was recorded, which was highly significant. Conclusion: A significant improvement in PaO2 was noted after inhaled corticosteroid use in patients with acute exacerbation of COPD, meanwhile a significant reduction in PaCO2 was also noted. Key Words: Chronic obstructive pulmonary disease (COPD), Acute exacerbation of COPD (AECOPD), forced expiratory volume in first second (FEV1), Peak expiratory flow rate (PEFR), St. George respiratory questionnaire score (SGRQ), Forced vital capacity (FVC).

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