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TITLE:

THE CLINICAL ASTHMA COURSE AND NEUROHORMONAL STATUS AT PATIENTS WITH OBESITY

AUTHORS:

Ludmila Tribuntseva, Sergey Avdeev, Andrey Budnevsky, Svetlana Kozhevnikova, Yanina Shkatova

ABSTRACT:

The purpose of this study was to reveal the interrelation between neuropeptide Y level and particularity of clinical asthma course at patients with obesity and overweight. Materials and Methods: We examined 113 patients with asthma aged from 18 to 75 years. The asthma diagnosis was based on Global Strategy for Asthma Management and Prevention, GINA, updated 2018. We analysed the clinical (number of asthma exacerbations, ambulance calls, and hospital admissions, Asthma Control Test), instrumental and laboratory status of patients. The patients were divided into 3 groups. Group I included patients with standard weight, body mass index (BMI) was from 18.5 to 24.99; Group II included patients with overweight, BMI was from 25.0 to 29.99; Group III included patients with obesity, BMI was more then 30. All data was evaluated with STATGRAPHICS 5.1, Microsoft Office Excel, Statistica 8.0. Results: patients with asthma and obesity had statistically higher level of neuropeptide Y. It had inverse correlation with spirometrical data, asthma control and direct correlation with level of molecules general oxidizing damage. It demonstrates the possible pro-inflammatory effect of neuropeptide Y, promoting the unfavourable asthma course. Thus, the research of the interrelation between neuropeptide Y and asthma course is necessary for establishment of degree and mechanism of neurohormone influence on disease pathogenesis. Keywords: asthma, obesity, neuropeptide Y, leptin, adiponectin

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