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ANALYSIS OF SERUM LEVELS OF CYSTATIN-C FOR THE EARLY DETECTION OF PRE-HYPERTENSIVE NEPHROPATHY

Dr Nadia Umar, Dr Waqar Shad, Dr Kiran Sadiq

Introduction: Chronic kidney disease (CKD) is common in geriatric cats, with a prevalence from 30% up to 60% in cats older than 10 years. Aims and objectives: The main objective of the study is to analyse the serum levels of Cystatin-C for the early detection of pre-hypertensive nephropathy. Material and methods: This cross sectional study was conducted in Ayub Medical College, Abottabad during November 2018 to March 2019. The data was collected from 100 nephropathic patients. The data was collected through non-probability sampling technique. Those with slightly raised serum creatinine and those with blood sugar levels within pre-diabetes range on previous reports were excluded, and so were those who gave history of antihypertensive medication or use of steroid. Informed consent was taken from all study participants. Results: The study subjects included 80 patients, 48 of them were male (60%) and 32 were female (40%). With a mean age of 59.85 ± 9.976 and age range of 41-80 years. All patients underwent elective CAG or PCI. According to the presented data and to the definition CIN and its grading in our study, CIN occurred in 19 patients 23.8%. The incidence of CIN was 0.0% in patients with serum creatinine increase <25% above baseline. While incidence in those with serum creatinine increase ≥ 25%. Conclusion: It is concluded that cystatin C is the leading biomarker in the early detection of pre hypertensive nephropathy. Diagnostic markers which reflect renal impairment at early stage is important as early intervention can slow the loss of kidney function and reduce adverse clinical outcomes.

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