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Krishnamurthy B*, Yogananda R , Bharathi D. R


The present study describes formulation and evaluation of nanoparticulate systems containing Acarbose by using synthetic polymers Eudragit RS 100 and eudragit RSPO for the treatment of type 2 Diabetes mellitus. The prepared Nanoparticles were evaluated for Surface morphology, Drug entrapment efficiency, differential scanning colorimetry, particle size, fourier transform infrared spectroscopy, in-vitro drug release and X-ray diffraction studies. The prepared Nanoparticles are smooth in surface and showing spherical shape. The average particle size of the nanoparticles were found in the range of 523 nm to 901 nm. The drug encapsulation efficiency (EE) of the Acarbose nanoparticles were found in the range of 82.21%to 89.30%. Here the drug encapsulation efficiency of prepared nanoparticles were increased with increase in the concentration of the polymer. The X-ray diffractogram of Acarbose has shown characteristic intense peak between the 2Ө of 19.67 and 30 due to its crystalline nature. Where as in case of drug free Nanoparticles, no intense peaks related to drug. In drug loaded Nanoparticles peaks were noticed between 2Ө of 29.67 and 49. The in-vitro drug release data of all the formulations were found to be zero order and shown sustained release over a period of 24 h. The FTIR Spectra’s of Nanoparticles formulation are compared with the spectra of pure drug of Acarbose and there is no much deviation in the spectra’s and not observed any drug and polymer interactions. The short time stability study of optimized formulation has done and subjected to drug encapsulation efficiency and In-vitro drug release studies, where results shown that there is no significant change in the formulation. Keywords: Acarbose, Nanoparticles, Eudragit RS 100, Eudragit RSPO.


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