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ANALYSIS OF SALIVARY BIOMARKERS CORRELATED WITH DIFFERENT PARAMETERS OF TOBACCO USE AMONG LOCAL POPULATION OF PAKISTAN

Dr Asma Saeed, Dr Nagina Nawaz, Dr Muhammad Yalmaz Masood

Introduction: The biochemical signaling involved in the periodontal disease inflammatory disease process consists of three biological phases i.e. inflammation, connective tissue degradation, and alveolar bone turnover. Aims and objectives: The main objective of the study is to analyze the salivary biomarkers correlated with different parameters of tobacco use among local population of Pakistan. Material and methods: This cross sectional study was conducted in Lahore general hospital, Lahore during November 2018 to March 2019. The data was collected from 100 patients who were used tobacco from last one year. The age range for this study was 200 to 60 years. Age, duration of use of tobacco, frequency of use, type of tobacco used and site of placement of tobacco in oral cavity were noted. Results: The data was collected from 100 participants. The mean age of the participants was 35.65 years. Levels of salivary IL-8 were found from 173. 48 pg/ml to 296.78 pg/ml with mean and standard deviation of 173.48±46.52pg/ml. Regarding educational status in tobacco users and non-users, 59.5% and 36.4% were uneducated, respectively. Most common reason for using tobacco was that they were just addicted to it. Conclusion: It is concluded that there was a high level of IL-8 were present in tobacco users. There is a positive correlation between salivary biomarkers and IL-8 levels and frequency of tobacco usage.

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