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FORMULATION AND INVITRO EVALUATION OF ATOMEXETINE BUCCAL PATCH BY SOLVENT CASTING METHOD

Karthika*, N. Sandeepthi,Nellutla Jhancy Laxmi

Amongst the various routes of administration tried so far in the novel drug delivery systems, localized drug delivery to tissues of the oral cavity has been investigated for the treatment of periodontal disease, bacterial and fungal infection. Over the decades mucoadhesion has become popular for its potential to optimize localized drug delivery, by retaining a dosage form at the site of action (e.g. within the gastrointestinal tract) or systemic delivery by retaining the formulation in intimate contact with the absorption site (e.g. buccal cavity.)[1] Well defined bioadhesion is the ability of a material (synthetic or biological) to adhere to a biological tissue for an extended period of time. The biological surface can be epithelial tissue or it can be the mucus coat on the surface of a tissue. If adhesion is to a mucous coat, the phenomenon is referred to as mucoadhesion. KEY WORDS: Mucoadhesion , Buccal cavity , gastrointestinal tract

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