::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

News Updates Latest Volumes: COSMOS IMPACT FACTOR (2018)- 4.153, GLOBAL IMPACT FACTOR(2014) - 0.384, (2015) - 0.437, Indo American Journal of Pharmaceutical Sciences,

ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

TITLE:

TO DETERMINE THE HEMATOLOGICAL CAUSES OF HYPERBILIRUBINEMIA IN NEONATES UNDERWENT EXCHANGE TRANSFUSION

AUTHORS:

Dr Muhammad Sanaullah , Dr Saadia Qureshi, Dr Junaid-ur-Rehman

ABSTRACT:

Aim: The purpose of this study was to determine the incompatibility of G6PD, Rh and ABO in newborns with severe hyperbilirubinemia who underwent exchange transfusion. Place and Duration: In the pediatrics Unit II of Jinnah hospital Lahore for one year duration from March 2019 to March 2020. Materials and methods: Records of all (131) newborns who underwent exchange transfusion were reviewed. Data collected included age, gender, weight, total and direct bilirubin levels, direct Coombs test results, hemoglobin levels, hematocrit results and G6PD qualitative test results. Patients were divided into two groups: a normal enzyme group and a group deficient in G6PD activity. All data was analyzed by statistical tests using SPSS ver. 13.0 (Chicago, IL, USA). Results: Out of 1970 newborns admitted for jaundice, 131 (6.6%) cases required replacement transfusion; the total number of exchange transfusions was 168. Factors requiring exchange transfusions were not identified in 51 (38.9%) newborns, while G6PD deficiency was the most common known cause of hyperbilirubinamia (43 newborns; 33%). Of the transfused patients, 93 (70.9%) were born on term, 74 (56.4%) were male, and 95% had normal body weight after birth. Most exchanges (51.1%) were carried out at the age of 2-4 days. Hemolysis was present in 11.6% of newborns with G6PD deficiency and in 11.3% of newborns with normal G6PD activity (P = 0.981). In patients with G6PD deficiency, the average age of onset of jaundice and exchange transfusion was 3 and 4.2 days after birth, respectively; in neonates with normal enzymes this age was 3.2 and 4.7 days after birth, respectively. Conclusion: In this study, the most common cause of severe jaundice leading to exchange transfusion was G6PD deficiency (33%) without hemolysis. KEYWORDS: neonatal jaundice; exchange transfusion; G6PD deficiency; haemolysis; kernicterus