::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

FREQUENCY OF ANTI-HCV IN PATIENTS ON MAINTENANCE HEMODIALYSIS AND ITS ASSOCIATION WITH PAST BLOOD TRANSFUSION HISTORYAND PRACTICES OF HEMODIALYSIS

AUTHORS:

Dr Maham Khan, Dr Arooj Shabbir, Dr Muhammad Salman

ABSTRACT:

Objectives: This research work aimed to find out the rate of occurrence of anti-HCV among patients having maintenance HD (Hemodialysis) and its relationship with the past history of transfusion of blood as well as practice of hemodialysis in different centers. Methodology: All patients under maintenance hemodialysis at Allied Hospital Faisalabad from September to August of 2019 were the participants of this research work. We recorded the details about demography, past history of transfusion of blood and history of hemodialysis from any other health center in addition with Allied Hospital Faisalabad. Chemiluminescent assay was in use for conduction of anti-HCV. We used Chi square method for the comparison of various categorical variables. We calculated the RR (Relative Risk) and OR (Odds Ratio) for the patients of groups for exposure risk. Results: Out of ninety six patients, 41.60% (n: 40) patients were positive for anti-HCV. Total 64.60% (n: 62) patients were present with past history of transfusion. Fifty percent (n: 31) of these sixty two patients were anti-HCV positive in comparison with the 26.50% (n: 9) out of thirty four patients were with no past history of blood transfusion (P= 0.0250); OR= 2.780 (P=0.02780), RR= 1.890 (P= 0.0420). Among 68.70% (n: 66) out of total ninety six patients who were under HD from various other centers in addition with our institute, 50.0% (n: 33) patients were positive for anti-HCV in comparison with 23.30% (n: 7) of twenty three who had hemodialysis from our institute only (P= 0.0140); OR= 3.290 (P= 0.0167), RR= 2.140 (P= 0.03090). Conclusion: There was very high incidence (41.60%) of anti-HCV in patients under HD and there was strong association of positivity of anti-HCV with the past history of the transfusion of blood as well as past history of hemodialysis from different centers. KEYWORDS: Incidence, anti-HCV, transfusion, hemodialysis, comparison, categorical, variables, OR, RR, Chi-square, renal diseases.