- CODEN : IAJPBB
- issn 2349-7750
TITLE:
COMPARATIVE STUDY OF INTRAVENOUS QUININE VERSUS INTRAMUSCULAR ARTEMETHER IN THE CEREBRAL MALARIA TREATMENT AMONG CHILDREN
AUTHORS:
Dr Iqra Rahim, Dr Haroon Rafique, Dr Iqtaza Arif
ABSTRACT:
Aim: To compare the effectiveness of intramuscular artemether with intravenous quinine sulphate infusion in cases of cerebral malaria. Study design: A randomized clinical trial. Place and Duration: In the Pediatric department of Benazir Bhutto Hospital, Rawalpindi for one year duration from March 2019 to March 2020. Methods: The study cases were divided in to two groups. Group A and B patients were treated with intramuscular artemether and intravenous quinine respectively to compare the effectiveness of the two drugs in cerebral malaria. Results: There were 34 patients with cerebral malaria in each group. In group A there were 20 (58.82%) men and 14 (41.18%) women. In group B there were 21 (61.76%) men and 13 (38.24%) women. (P = 1.0000). The ratio of men to women in groups A and B was 1.42: 1 and 1.61: 1. The average age of patients in groups A and B was 7.6 years + 4.2 SD and 7.0 years + 4.3, respectively SD (p = 0.5625). The average recovery time for patients with cerebral malaria in groups A and B was 24.8 hours + 9.3 SD and 30.5 hours + 9.1 SD, respectively (p = 0.0130). Mortality in groups A and B was 4 (11.76%) and 5 (14.71%) cases, respectively (p = 1.0000). Conclusion: Intramuscular artemeter was more effective than intravenous quinine infusion in cerebral malaria. Key words: cerebral malaria, coma, intramuscular artery, intravenous quinine
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Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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