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TITLE:

TO DETERMINE THE SAFETY OF ANTI-EPILEPTIC DRUGS IN CHILDREN TREATED FOR SEIZURES

AUTHORS:

Muhammad Irfan, Muhammad Adnan, Usman Hafeez, Moazzam Hussain

ABSTRACT:

Epilepsy is a neurological disorder in which recurring seizures occur in the person. It is most common childhood disorder in United State. The seizures in a children start with the changes in electrical as well as chemical changes in the brain. There are various types of seizures such as absence seizures, atonic seizures, myoclonic seizures, febrile seizures and tonic-clonic seizures. Age is major factor to determine the recurrence of seizures and types of seizures. The sign and symptoms of epilepsy are convulsion with no fever, anger, jerking arms, sudden blinking, sudden stiffness and so on. Some drugs are considered more safe in children for the treatment of seizures. Objective: The objective of this study is to determine the safety of epileptic drugs used for treatment of epilepsy or seizures in children. Methods: A prospective study was conducted to determine the safety of epileptic drugs used for the treatment of epilepsy in children. The data was collected of almost 150 children who are epileptic patient whose treatment is going in the hospital and they follow their treatment plan carefully. The data was collected from the patient fulfilled the inclusion and exclusion criteria then findings are noted and recorded. The data was analyzed by computer software SPSS and data were assessed by statistical t-test. Results: The results of this study shows that the drugs used in children for the treatment of seizures are safe. The side effects of these drugs are most commonly in males and thus the duration of seizures in first thirty minutes is worst. The prevalence of Status epilepticus is most commonly occurring at the age of 1-5 years. There are no severe side effects have been seen which shows that the drugs used are very safe to use in children Conclusion: Epilepsy or seizures are known as the most common brain disorder in United States and if it is not treated at the time it becomes more severe. The treatment plan for the children is different from the adults and the drugs used for their treatment are safe and cause very less side effects. Thus it is concluded that the use of these drugs are safe in children is safe. Keywords: Seizures, Children, Antiepileptic drugs, Safe drugs.

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