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Dr Summaya Zaitoon, Dr Ayesha Mubeen, Dr Safa Imad Ahmad


Objective: We aimed in this analysis to describe the rate of Thrombocytopenia in long lasting dynamic hepatitis C occurred due to hepatitis C virus HCV. Study design: Cross Sectional study. Place and duration of study: This analysis was conducted in the Hematology department of Islam medical College and Islam Teaching Hospital, Sialkot for a duration of 6 months from September 2019 to February 2020. Methodology: A total number of 150 patients were analyzed in this study. The HCV was suggested to be the major etiological cause of Chronic liver disease. Thrombocytopenia was a usual complexity in chronic liver disease (CLD) cases which was found in patients with the percentage of 76.0 %. This happens because of the destruction of bone marrow and splenic platelet confiscation through antiviral treatment and Chronic hepatitis C. Necessary information of patients like name, age and address was collected and samplings was taken and tested for complete blood count (CBC) and platelet count (PLT). Sysmex XT 1800i was used for this analyzation. The total gathered data was inserted into the SPSS 10.0 and was studied by its package of statistics. Age was shown as average and Standard deviation SD and gender and platelet count was presented as frequency and percentages. Results: The patients of current study were 150 in number and comprised of female and male as 99 and 51 with the percentage of 66.0 % and 34.0 % respectively. Limit of age was from 18 years to 78 years. Average was 41.9 ± 12.8 years of age. Maximum patients were in last stage of life. Average platelet count was 41.9 ± 77.3 x 109/1 where range was 150.0 to 400.0 x 109/1. Thrombocytopenia was existing in number of 34 patients out of total with the percentage of 22.6 %.The separation of patients was made into two groups based on their age. Group A was consisting of patients having age more than or equal to 40 years and Group B consists of patients with age less than 40 years, Group A and Group B have 87 and 63 number of patients with the percentage of 58.0 % and 42.0 % respectively out of 150 patients in this study. Group A with the percentage of 26.4 % have most usual thrombocytopenia versus Group B with the percentage of just 17.4 % of thrombocytopenia.The outcomes of the current analysis shown the percentage of 22.6 % as the rate of thrombocytopenia in the patients of Chronic Active Hepatitis (CAH).As the rates were studied through chi square and T-test, the maximum degree and ratio of thrombocytopenia in Group A was gotten indefinite according to statistics. Conclusion: It is found that diagnosis of HCV associated with thrombocytopenia is in accordance with the rule that suppression of Hepatitis C virus (HCV) infection would be predicted as reduction of thrombocytopenia. For the procession of diagnosis without any interference, the patients require hematological growth element who were progressing the deviations of hematology. Key Words: Thrombocytopenia, Hepatitis C, Chronic Active Hepatitis (CAH), Hepatitis C virus (HCV).


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