::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EVALUATION OF SERUM FERRITIN LEVELS IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

AUTHORS:

Dr Anam, Dr Rizwan Rabbani, Dr Zeeshan Ahmad

ABSTRACT:

Objective: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although the increase in serum ferritin levels in many forms of malignancies is known, the growing pattern with different stages of ALL has not yet been explained. Aim: To assess serum ferritin, uric acid and LDH in patients with acute lymphoblastic leukemia. Place and Duration: In the Pediatric Unit II and Pediatric Oncology department of Jinnah Hospital Lahore for one year duration from March 2019 to March 2020. Material and method: This is a case-control study. 80 ALL patients were registered in this study, for a total of 160 cases; and 80 healthy gender issues as controls. All test results were statistically analyzed using the Statistical Package for Social Sciences (SPSS) version 20.0. Results: In this study, 160 selectees, 80 ALL patients, 42 patients (52.5%) were men, and 38 reminders (47.5%) were women. The mean age in the group of cases was 17.6 ± 5.6. The control group included 80 healthy people aged (17.8 ± 12.1) and sex (52.5% men, 47.5% women). Statistically significant positive correlations were found between the number of serum ferritin levels in blast cells (r = 0.735, p <0.0001) and uric acid (r = 0.618, p <0.0001) and LDH (r =) in ALL patients. 0.570, p <0.0001). Conclusion: ALL was associated with high serum ferritin. Serum ferritin levels were significantly correlated with various stages of the disease and had a positive linear correlation with serum uric acid, LDH and blast number, so serum ferritin can be used as prognostic markers for ALL. Key words: serum ferritin, acute lymphoblastic leukemia, blood.