Dr Fauzia Khan, Dr Atif Abbas, Dr Wajid Hussain, Dr Tahir Iqbal, Dr Muhammad Abdul Quddus
Objective: Lupus erythematosus is an autoimmune disease with pronounced pleotropism. If several systems are involved, the disease is called systemic lupus erythematosus (SLE) and if the skin only involved exclusively the term discoid lupus erythematosus (DLE) is used. One of several Histopathological features of DLE include periappendageal inflammation. It sometimes Eliminate the sebaceous glands that make up the granulomas. Aim: To determine the frequency of sebaceous granuloma formation in discoid lupus erythematosus. Study Design: An Observational prospective study. Place and Duration: In the department of Medicine, Fauji Foundation Hospital Rawalpindi for one year duration from January 2019 to January 2020. Material and method: This prospective observational study was conducted in pathology and Dermatology department of Services Institute of Medical Sciences, Lahore for one year duration from February 2019 to February 2020. 110 DLE cases selected for one year duration between the ages of 4 and 70 for the occurrence of sebaceous granuloma. Other DLE features, such as follicular plugging, hyperkeratosis, vacuolization of the base layer, epidermal atrophy, periappendageal inflammation, perivascular inflammation, periorbital inflammation and collagen damage was also distinguished. Results: 18 of these 110 cases had sebaceous granuloma. These granulomas consists of foreign body giant cells, epithelial cells containing partially digested sebaceous material and some lymphocytes. Conclusion: Sebaceous granuloma formation was observed in 16.4% of DLE cases. This feature should be recognized by both pathologists and dermatologists for DLE diagnosis. Due to the presence of granulomas, an incorrect and incomplete diagnosis cannot be made. Keywords: Sebaceous granulomas, hyperkeratosis, epidermal atrophy, Discoid lupus erythematosus (DLE).