::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY TO KNOW METABOLIC SYNDROME AMONG POSTMENOPAUSAL WOMEN AND EFFECTS OF VITAMIN D

AUTHORS:

Dr Shayan Idrees, Dr Aimen Khurshid, Dr Nabhan Ahmed

ABSTRACT:

Background: Metabolic syndrome (MS) is a group of metabolic risk factors for cardiovascular diseases (CVD). Postmenopausal women may have an increased risk of MS and CVD. Vitamin-D (Vit-D) have an important role in the progression of CVD. Aim: This study was conducted to assess the link between Vit-D and MS among postmenopausal women. Study Design: A cross-sectional study was carried out; in the department of gynecology, Mayo Hospital Lahore from October 2019 to March 2020. Materials and Methods: A total of 288 postmenopausal women were enrolled in the study Anthropometric measurements were measured using the standard procedure. Blood samples were collected and Vit-D levels of all participants were estimated. The study population was further grouped into three based on the Vit-D status as Vit-D deficient, Vit-D insufficient Vit-D normal group. Other parameters such as blood glucose, TC, TG, HDL, and LDL were measured and metabolic syndrome was identified. Result: There was a significant difference in the prevalence of MS between the groups. The one way ANOVA between the groups showed a significant difference (p≤0.05) for the components of MS such as waist circumference, BP, FBS, HDL-C. The Triglycerides levels did not show a significant difference between the groups. The Person correlation test indicated a negative correlation between Vit-D and the components of MS except for HDL-C. Conclusion: Vitamin-D deficiency was highly prevalent in menopausal women and serum Vit- D levels were significantly correlated with the prevalence of MS in postmenopausal women; this finding indicates that Vit-D could be an important factor for the development of MS and further CVD. Keywords: Metabolic syndrome, Vitamin D, menopause, Cardiovascular risk.