Dhanashree Devre, Dr. Ganesh Deshmukh, Hrutuja Padge, Chetan Khade
The objective of controlled drug delivery systems is to reduce the frequency of the dosing and to increase the effectiveness of the drug by localization. In oral controlled drug delivery systems, multiple unit dosage forms (MUDFs), like granules, pellets and mini tablets effectively control the release of the drug when compared to single unit dosage forms (SUDFs) like tablets and capsules. Among all MUDFs, mini-tablets offer several advantages like they can be manufactured relatively easily, they do not require any solvent for their production, can be coated reproducibly, and also requires less coating material. Also, there is a great flexibility during their formulation development. In this context, last few decades have witnessed some major advancement. Mini tablets are more acceptable in children and elderly people as they are easy to swallow. Mini tablets are effective and alternative solution for single unit dosage forms. Dose dumping and local irritation can be avoided by the use of mini tablets. Among all MUDFs, mini tablets represent a new trend in solid dosage form design, with the main aim of overcoming drug-excipients or drug-drug interactions. They also offer an alternative for pellets and granules because of their relative ease of manufacturing and dosage forms of equal dimensions, weight with smooth regular surface can be produced in a reproducible and continuous way. Therefore, they resemble good substitutes for pellets and granules. They can also be filled in capsules like other multiple unit dosage forms. Focused on how mini tablet formulation become effective in targeted and modified drug delivery system. This review emphasizes the various advantages of mini-tablets, formulation possibilities, general evaluation tests, and brief insight to marketed drugs. Keywords: Single unit dosage form, Multi unit dosage form, Mini tablets, pellets, granules.