::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY TO KNOW THE ASSOCIATION BETWEEN LIVER CIRRHOSIS AND PULMONARY FIBROSIS IN PATIENTS VISITED TERTIARY CARE HOSPITAL

AUTHORS:

Dr Sayeda Sobia Qasim, Dr Shahla Riaz, Dr Amna Khan Sherwani

ABSTRACT:

Objective: To know the association between pulmonary fibrosis and liver cirrhosis in various cirrhosis groups according to the age classification. Study design: This is a descriptive study. Place and Duration: Study conducted in the medicine department of Mayo Hospital, Lahore for the duration of Six Months from October 2019 to March 2020. Methodology: Fifty patients were included in the study. All patients over 20 years of age are offered in the outpatient department, accident and emergency department and admitted to the medical unit. Patients were comparable in terms of age, sex, and physical characteristics, and the frequency of pulmonary fibrosis and child's classes were observed. Results: The prevalence of hepatitis C is higher than that of hepatitis B. The causes of cirrhosis are the same as fibrosis. In developed countries, most cases are caused by chronic alcohol abuse or chronic hepatitis C. In some parts of Asia and Africa, cirrhosis is often due to chronic hepatitis B. Pulmonary fibrosis is an important component of many common parenchymal or interstitial lung diseases. Fifty patients included in the study were with mean age of 36.67 ± 8.35 ± SD between 20-25 years of age. Fifty-six percent were male patients and 44% were female and female / male ratio was 1.27: 1. 18 (38%), mean ± SD was 1.31 ± 0.21 and only 1 (2%) patient left the study. There were 9 patients in class A (18%), 16 children in class B (32%) and 22 patients in class C (44%). Each patient's class was assigned according to two clinical criteria and three laboratory criteria as defined in the CTP system. Twenty-two (44%) of 50 patients had laboratory or clinical criteria for pulmonary fibrosis in cirrhosis. Twenty-six (52%) were missing and only 2 (4%) were missing due to error in studies. The ultrasound findings of portal hypertension, ie the reduction of liver span was 50 (100%) time and portal vein dilatation was 10 (20%). Splenomegaly was absent in 9 patients (18%) and 5 patients (10%) had present and ascities in 13(26%) patients and absent in 4(8%). Pulmonary fibrosis and liver cirrhosis were statistically significant. The difference of the test was significant (p <0.05). Conclusion: There is a significant relationship between pulmonary fibrosis and liver cirrhosis and it increases the incidence of pulmonary fibrosis with the progression of child’s classification. Key words: liver cirrhosis, pulmonary fibrosis and Childs classification.