Volume : 10, Issue : 04, April – 2023
Title:
42.ENHANCEMENT OF SOLUBILITY OF NIFEDIPINE BY USING SOLID DISPERSION TECHINIQUE
Authors :
M. Sai Vishnu,* T. Sravani, T. Bala Krishna
Abstract :
The present work was aimed to enhancement of solubility of Nifedipine by using solid dispersion technique by kneading technique. Nifedipine is a class II drug and hence it is formulated by using solid dispersion technique to increase solubility of drug with the aid of polyvinyl pyrrolidine. Solid dispersion was prepared by combining of drug and carrier. The physical mixtures were prepared by solvent evaporation technique accordingly with the composition given in table. The ingredients like drug and carrier were accurately weighed (in different ratios 1:1, 1:1.5, 1:2, 1:2.5 1:3, 1:3.5, 1:4) and mixed in porcelain dish with a stirrer for 10 min to get uniform mix by using methanol. The above substance was dried. These are sieved to obtain granules by using sieve no.20. The blended powder was filled into capsules. The observed results reveals that carrier have significant effect on drug release up to 1 hr after successful development of solid dispersion containing Nifedipine and polyvinyl pyrrolidine carrier in different ratios(1:1, 1:1.5, 1:2, 1:2.5 1:3, 1:3.5, 1:4).
Key words: Nifedipine, Solid Dispersion, polyvinyl pyrrolidine, Kneading Method, methanol.
Cite This Article:
Please cite this article in press M. Sai Vishnu et al, Enhancement Of Solubility Of Nifedipine By Using Solid Dispersion Technique., Indo Am. J. P. Sci, 2023; 10 (04).
Number of Downloads : 10
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