Volume : 11, Issue : 07, July – 2024

Title:

FORMULATION AND EVALUATION OF ALOIN LOADED MICROSPHERES TO TREAT DIABETES

Authors :

Shivani Rai*, Suneel Kumar Jain, Yashwant Singh Jat

Abstract :

This study focuses on the formulation and evaluation of aloin-loaded microspheres for the treatment of diabetes. Microspheres were prepared using the Solvent Evaporation method with a mixture of ethanol and dichloromethane as solvents. The formulations (F1 to F5) varied in their composition of aloin, HPMC (Hydroxypropyl methylcellulose), and EC (Ethyl cellulose). The physical characteristics including particle size, polydispersity index (PI), zeta potential, entrapment efficacy, and stability of the microspheres were extensively evaluated. The results showed that the particle size of the microspheres ranged from 150.4 nm to 178.1 nm, with formulations F1 and F3 demonstrating the smallest sizes and narrower size distributions. Zeta potential measurements indicated that formulations F2, F4, and F5 had positive potentials, suggesting a tendency towards aggregation, while F1 and F3 had lower potentials, indicating better stability. Entrapment efficacy varied from 84.16% to 93.07%, with formulations F1 and F2 exhibiting the highest encapsulation efficiencies. Stability studies conducted under different conditions (25°C ± 2°C and 60 ± 5% RH, and 40°C ± 2°C and 70 ± 5% RH) demonstrated that formulation F1 maintained consistent particle size and high entrapment efficacy over a 90-day period, indicating good physical and chemical stability suitable for potential clinical applications.
Keywords: Aloin, microspheres, solvent evaporation method, diabetes treatment, particle size, polydispersity index, zeta potential, entrapment efficacy, stability study.

Cite This Article:

Please cite this article in press Shivani Rai et al Formulation And Evaluation Of Aloin Loaded Microspheres To Treat Diabetes.,Indo Am. J. P. Sci, 2024; 11 (07).

Number of Downloads : 10

References:

1. American Diabetes Association. Standards of Medical Care in Diabetes – 2023. Diabetes Care. 2023;46(Suppl 1)
2. Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271-281.
3. Yagi A, Hegazy S, Kabbash A, et al. Hypoglycemic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytother Res. 1999;13(3):203-204.
4. Rajasekaran S, Sivagnanam K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food. 2004;7(1):61-66.
5. Jain AK, Jain A, Garg NK, et al. Drug delivery systems having top-down approach for translation: a review. Curr Drug Deliv. 2013;10(5):527-547.
6. Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm Res. 1998;15(9):1326-1331.
7. Fartyal, S., Jha, S. K., Karchuli, M. S., Gupta, R., & Vajpayee, A. (2011). Formulation and evaluation of floating microspheres of boswellic acid. Int J Pharm Tech Res, 3, 76-81.
8. Singh, K. K., & Vingkar, S. K. (2008). Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. International Journal of Pharmaceutics, 347(1-2), 136-143.
9. Deshmukh, R., Harwansh, R. K., Prajapati, M., & Sharma, B. (2023). Formulation and Evaluation of Oral Mucoadhesive Microspheres of Ofloxacin for Peptic Ulcer Use. Trends in Sciences, 20(9), 5751-5751.
10. Bodmeier, R., & Chen, H. (1989). Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen. Journal of controlled release, 10(2), 167-175.
11. Ahmed, M. M., Fatima, F., Kalam, M. A., Alshamsan, A., Soliman, G. A., Shaikh, A. A., & Anwer, M. K. (2020). Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats. Saudi Pharmaceutical Journal, 28(12), 1817-1826.