Volume : 11, Issue : 07, July – 2024
Title:
FORMULATION AND EVALUATION OF FLOATING TABLETS OF METOPROLOL TARTARATE BY USING NATURAL POLYMERS
Authors :
S.Rohini* , M. Ramya Teja and J. N. Suresh Kumar
Abstract :
The aim of present research work is to formulate and evaluate controlled release floating tablet of Metoprolol tartaratein view to enhance bioavailability and therapeutic action.The tablets were formulated by employing wet granulation method using PVP K 30 as binder and isopropyl alcohol as granulating fluid. The granules were evaluated for flow properties. All the formulations showed values within the prescribed limits for tests like hardness, friability and weight variation which indicate that the prepared tablets are of standard quality. All the tablets were formulated using sodium bicarbonate as effervescent agent. All the prepared formulations floated immediately after placing into the beaker and the floating was maintained more than 14 hrs. It was observed that the carbon dioxide generated from sodium bicarbonate in presence of dissolution medium(0.1N HCL) was trapped in the polymer gel matrix formed by the hydration of polymer which decreases the density(<1) and makes the tablet buoyant. The correlation coefficient values (r) revealed that the dissolution profiles followed Zero order kinetics and the mechanism of drug release was governed by Peppas model. The n values are found to be more than 0.5 (n>0.5) indicted that the drug release was predominantly controlled by non fickian diffusion. Based on the release rate constant and % of drug release the formulations prepared with Moringa oleifera shown prolonged retarding nature compared with the formulations prepared with Gum karayaleaves mucilage. Among all the formulations , F3 formulation containing drug and Moringa oleifera in 1:1.5 ratio was found to be optimized formulations.
Key words: Metoprolol tartarate,Moringa oleifera, Gum karayal,Sodium bicarbonate
Cite This Article:
Please cite this article in press S.Rohini et al., Formulation And Evaluation Of Floating Tablets Of Metoprolol Tartarate By Using Natural Polymers., Indo Am. J. P. Sci, 2024; 11 (07).
Number of Downloads : 10
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