26.Issue 07 july 24 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 11, Issue : 07, July – 2024

Title:

ADIPOSIS DOLOROSA: A COMPREHENSIVE REVIEW OF CLINICAL PRESENTATION AND MANAGEMENT

Authors :

Daphne Sherine.S, Hemapriya.M, Mohan Kumar.J, Manisha.M, Kavya.K

Abstract :

Dercum’s disease, commonly known as adiposis dolorosa, is an uncommon condition marked by the growth of many, excruciating lipomas in the adipose tissue. Middle-aged women are the main population affected by this ailment, which causes chronic pain that drastically lowers quality of life. Although the exact cause of adiposis dolorosa is unknown, it is thought to be related to immunological, hormonal, and metabolic processes. Clinically, patients present with palpably sore subcutaneous nodules and plaques, frequently accompanied by systemic symptoms such weakness, weariness, and cognitive impairments. The existence of distinctively painful lipomas is the primary basis for the diagnosis, which frequently necessitates ruling out other disorders that may be comparable. While imaging tests like MRIs and ultrasounds can help assess lipomas, they cannot provide a conclusive diagnosis. The few available treatments are primarily symptomatic and concentrate on managing pain with pharmaceuticals like analgesics and anti-inflammatory medicines as well as physical therapy. Although surgical removal of lipomas is linked to risks and recurrence, it can offer comfort. Novel pharmaceutical methods, liposuction, and injections of local anesthetic are among the emerging remedies being studied. The recurrent and chronic nature of adiposis dolorosa places a significant burden on patients, requiring ongoing study to better understand the underlying causes and find appropriate treatments, as well as interdisciplinary methods to therapy. To understand the pathogenesis and find viable treatment options for this crippling ailment, more research is necessary.
Keywords: Rare disorder, Painful lipomas, Subcutaneous nodules, Middle-aged women, Fatigue.

Cite This Article:

Please cite this article in press Daphne Sherine.S et al., Adiposis Dolorosa: A Comprehensive Review Of Clinical Presentation And Management, Indo Am. J. P. Sci, 2024; 11 (07).

Number of Downloads : 10

References:

1. Mehul J. Desai, Radhika Siriki, Dajie Wang, Treatment of Pain in Dercum’s disease with Lidoderm® (Lidocaine 5% patch): A case report, Pain Medicine. 2008; 9(8): 1224-1226. doi: https://doi.org/10.1111/j.1526-4637.2008.00417.x
2. Tiesenga F, FaroquiHm, Kaur K, Niazi S, Nijjar K, et.al. Dercum’s disease (adiposis dolorosa) & associated obesity. J Med case rep case series. 2(1): https://doi.org/10.38207/jmcrcs .20210010.
3. Jonelle M. Petscavage-Thomas. Eric A. Walker. Stephanic A. Bernard. Jennifer Bennett, Skeletal Radiol. 2015; 44: 839-847. doi: 10.1007/s00256-015-2114-8.
4. Wold LE, Hines EA Jr, Allen EV. Lipedema of the legs; a syndrome characterized by fat legs and edema. Ann Intern Med. 1951; 34(5): 1243-50. doi: 10.7326/0003-4819-34-5-1243.
5. Fӧldi E, Fӧldi M, Strӧssenreuther R, Kubik S. Lipedema. In: Fӧldi’s Textbook of lymphology. 2nd ed. Munich: Urban & Fisher; 2006. 416-427.
6. Hansson E, Svensson H, Brorson H. Review of Dercum’s disease and proposal of diagnostic criteria, diagnostic methodology & treatment. OrphanetJ of Rare disease. 2012; 7(23). doi:10.1186/1750-1172-7-23.
7. S. SelvaPriya. Dercum’s disease (adiposis dolorosa). Int. J. Nur. Edu. And Research. 2018; 6(4): 435-438. Doi: 10.5958/2454-2660.2018.00105.9.
8. Eugeniusz J. Kucharz, JustynaKramza, Monika Chrzanowska, Dercum’s disease (adiposis dolorosa): a review of clinical presentation and management. Reumatologia. 2019; 57(5): 281-281. doi: https://doi.org/10.5114/reum.2019.89521.
9. Bhagya Sri Palistty, ApoorvaPinisetti, Vinod Kumar Mugada, Srinivasa Rao Yarguntla. An in-depth review of Dercum’s disease: Aetiology, Epidemiology, and treatment. Asian J of research in pharmaceutical sciences. 2023; 13(4). doi: 10.52711/231-5659.2023.00049.
10. Fajgenbaum. Adiposis dolorosa: Areview of the literature. Journal of clical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Disease. 2019; 15(3): 237-244.
11. Lontchi-Yimagon E, Sobngwi E, Matsha TE, Kengne AP. Diabetes mellitus and inflammation. CurrDiab Rep. 2013; 13(3): 435-44. doi: 10.1007/s11892-013-0375-y.
12. Kirwan JP, Hinkle DE, Kleis SL, Masharani U, Gardner A, Gower BA. Dercum’s disease (Adiposis dolorosa): a case report and literature review. J ClinEndocrinolMetab. 2000; 85(10): 3557-9. doi:10.1210/jcem.85.10.6866.
13. Slavin RE, Gonzalez-Vitale JC. Dercum’s disease (Adiposis dolorosa): report of a case with postmortem findings. Arch Pathol Lab Med. 1974; 98(5): 386-90.
14. Herbst KL, Asare-Bediako S. Adiposis dolorosa (Dercum’s disease): etiology, diagnosis, and management strategies. Med Clin North Am. 2019; 103(6): 1155-1166. doi: 10.1016/j.mcna.2019.07.004.
15. Lanteri-Minet M, Valade D, Geraud G, Chautard MH, Lucas C. Epidemiology and treatment of chronic path with paroxysmal painful symptoms; a national study. J Pain Symptom manage. 2003; 26(4): 837-847. doi: 10.1016/s0885-3924(03)00301-5.
16. Tins BJ, Matthews C, Haddaway M, Cassar-Pullicino V, Lalam RK, Singh J, Tyrrell PN. Adiposis dolorosa (Dercum/s disease): MRI and Ultrasound appearances. ClinRadiol. 2013; 68(10): 1047-1053. doi: 10.116/j.crad.2013.03.013.
17. Svensson H, Brorson H, Hansson E, Liposuction may reduce pain in Dercum’s disease (Adiposis dolorosa). Pain Med. 2011; 12(6): 942-952.
18. Herbst KL. Subcutaneous adipose tissue diseases: Dercum’s disease, lipedema, familial multiple lipomatosis & Madelung disease. SurgClin North Am. 2008; 88(3):639-663.
19. Campen R, Mankin H. Adiposis dolorosa (Dercum’s disease): report of a case & review of the literature. J Bone Joint Surg Am. 1965; 47:1043-1047.
20. Manjer J, Hansson E, Svensson H, Brorson H. High prevalence of Dercum’s disease among women. Obes Surg. 2010; 20(7): 946-950.
21. Roux H. Nouvelle maladie nerve use: Adiposis dolorosa. Rev neurol (Paris). 1888; 6: 438-440.
22. Rutledge T, Herbst KL. Pilot study: rapid cycling hypobaric pressure improves pain after 5 days in adiposis dolorosa patients. J Pain Res. 2010; 3: 147-153.
23. Palumbo P, Cinque B,Lombardi F. Dercum’s disease or Adiposis dolorosa: a complex condition still awaiting full definition. Aesthetic medicine.2018;4.
24. Lӧffler M, Bauer T, Dietrich A, Balensiefen T, Rudofsky G. Adiposis dolorosa (Dercum’s disease) as a rare differential diagnosis of painful subcutaneous nodules. Int J Dermatol. 2006; 45(6): 739-40. Doi: 10.1111/j.1365-4632.2005.02662. x.
25. San H, Nishimura M, Kajihara H, Morimoto N, Sakamoto M, TashiroK. A case of adiposis dolorosa treated by surgical resection of subcutaneous fatty tissue. Ann Plast Surg. 1997; 39(4): 420-3. Doi: 10.1097/00000-00020.
26. Louis DN, Hirano M, Maccollin M, Campen R, Mankin H. Familial occurrence of Adiposis dolorosa. J Am AcadDermatol. 2001;44(1): 132-6. Doi: 10.1067/mjd.2001.109823.
27. Asare-Bediako S, Herbst KL. Adiposis dolorosa: a rare disease which needs more study. Am J Med Sci. 2018; 355(2): 175-182. Doi: 10.1016/j.amjms. 2017.08.010.
28. Sibbitt Jr. Adiposis dolorosa (Dercum’s disease): effective treatment with methotrexate. Southern Medical Journal. 2001; 94(7), 673-677.
29. Lange U, Eich W, Genth E. Adiposis dolorosa (Dercum’s disease) in rheumatology. Clinical and therapeutic aspects. Z Rheumatol. 2003; 32(1):33-9.
30. Felicetti M, Ferrara PE, Gigli GL. Painful adiposis of Dercum: symptomatic treatment with a new CO2 diode laser. Neurol Sci. 2001; 32(2):343-5.
31. Peck MA, Mannebach S. Dercum disease: Aunique presentation and treatment option. Ann Plast Surg. 2016; 77(1):108-9.
32. Al-Ghazal SK, Donnai P. Dercum’s disease: report on two casesand review of the literature. Clin Dysmorphol.1998;7(3):209-214. Doi: 10.1097/00019605-199807000.
33. Herbst KL. Adiposis dolorosa, an endocrine disease with immune manifestations? Implications for new therapeutic approaches. Expert Opin Orphan Drugs. 2013;1(9):735-747. Doi: 10.1517/21678707.2013.821501.
34. Brodovsky S, Westreich M, Leibowitz A, Schwartz Y. “Adiposis dolorosa (Dercum’s disease): 10-year follow-up”. Annals of Plastic surgery. 1994; 33: 664-668.
35. Juhlin l. Long-standing pain relief of adiposis dolorosa (Dercum’s disease) after intravenous infusion of lidocaine. J Am AcadDermatol. 1986;15(2): 383-385. Doi: 10.1016/S0190-9622(86)70143-8.
36. Petersen P, Kastrup J. Dercum’s disease 9adiposis dolorosa) Treatment of the severe pain with intravenous lidocaine. Pain. 1987;2891):77-80. Doi: 10.1016/0304-3959(87)91062-1.
37. Rosenstock J, Tuchmann M, LaMoreaux L. Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain. 2004;110(3):628-638. doi: 10.101/j.pain.2004.05.001.
38. Liptan GL.Fascia: A missing link in our understanding of the pathology of Dercum’s disease. J BodywMovTher. 2010;14(1):3-10. doi:10.1016 /j.jbmt.2008.12.002.
39. Monleόn S, Murillo J, Bad1a S, Munoz-Bonet JI. Effectiveness of acupuncture in the treatment of pain in Dercum’s disease: a case report. Acupunct Med. 2014;32(4):357-359. Doi: 10.1136/acupmed-2014-010634.
40. Sibbald RG, Woo KY, Ayello EA. Pain in chronic wounds: a narrative review. Int Wound J. 2-12;9(3):247-262. Doi: 10.1111/j.17420481X.2011.00875. x.