Volume : 11, Issue : 12, December – 2024
Title:
PREPARATION AND CHARACTERIZATION OF GASTRORETENTIVE TABLETS OF LOSARTAN POTASSIUM
Authors :
Ch Mounika, Zeenath Ruhy
Abstract :
The goal of a gastro-retentive drug delivery system is to target the upper GIT and maintain the medicine at a specific region of the GIT for a longer period. In this study, one of the least reported approaches, expandable drug delivery, was utilized. Losartan potassium expandable tablet was prepared by direct compression method. Various polymer concentrations were employed. To improve the drug’s bioavailability and prolong its duration in the stomach, expandable losartan potassium tablets were prepared. Based on the results of the evaluation it was found that the evaluatory parameters of tablets were within the acceptable limit of Pharmacopoeia. Formulations F8 and F12 could only keep the drug’s release continuing for 12 hours. All formulations were following zero order release. In contrast to formulations F2, F3, F5, and F8, which followed nonfickian (anomalous) drug release, F1, F4, F6, and F7 followed Fickian drug release. Formulation F8 was chosen as the optimal formulation.
Keywords: Losartan potassium, Gastroretentive expandable tablets, residence time, in-vitro release
Cite This Article:
Please cite this article in press Zeenath Ruhy et al ., Preparation And Characterization Of Gastroretentive Tablets Of Losartan Potassium .,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
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