Volume : 11, Issue : 12, December – 2024
Title:
FORMULATION DEVELOPMENT AND CHARACTERIZATION OF VORICONAZOLE NANOPARTICLES
Authors :
D. Shirisha, Dr.K Balaji
Abstract :
When it comes to developing new medications, nanoparticles offer hope since they allow for the regulated release of doses. They work wonderfully for localizing medications to the target tissue. Developing and evaluating voriconazole-containing Carbopol p934 nanoparticles in various polymer solutions was the objective of this work. Scanning electron microscopy revealed a distinct spherical shape for the nanoparticles. Evidence from the FT-IR facility disproves any chemical link between the medicine, the polymer, and the drug’s shelf life. All of the drug loading groups’ in vitro release lines were thought of as initial release, and they gave 12 hours of sustained release. The created remedy satisfies and lessens the negative aspects of the voriconazole sustained release definition, and it has the potential to increase the drug’s bioavailability in the future.
Keywords: Nanoparticles, PLGA, Carbopol p934, Eudragit RL and Voriconazole.
Cite This Article:
Please cite this article in press D. Shirisha et al Formulation Development And Characterization Of Voriconazole Nanoparticles .,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
References:
1. Hasan S 2015 A Review on Nanoparticles : Their Synthesis and Types Biosynthesis : Mechanism 4 9–11
2. Assessment R 2007 Nanoparticles in the Environment
3. Cho E J, Holback H, Liu K C, Abouelmagd S A, Park J and Yeo Y 2013 Nanoparticle characterization : State of the art , challenges , and emerging technologies.
4. Machado S, Pacheco J G, Nouws H P A, Albergaria J T and Delerue-Matos C 2015 Characterization of green zero-valent iron nanoparticles produced with tree leaf extracts Sci. Total Environ. 533 76–81.
5. Renu Tiruwa. A review on nanoparticles – preparation and evaluation parameters. Indian J. Pharm. Biol. Res. 2015; 4(2):27-31
6. Abhilash M., Potential applications of Nanoparticles, International Journal of Pharma and Bio Sciences 2010; 1:1: 1-12.
7. Nagavarma B. V. N., Hemant K. S. Yadav, Ayuz A., Vasudha L.S., Shivakumar H.G, Different techniques for preparation of polymeric nanoparticles – A Review, Asian Journal of Pharmaceutical and Clinical Research 2012; 5:3: 1-8.
8. A. R. Mullaicharam, Nanoparticles in drug delivery system, International Journal of Nutrition, Pharmacology Neurological Diseases 2011; 1:2: 103-121.
9. Langer R. Biomaterials in drug delivery and tissue engineering; one labortory’s experience. Acc ChemRes.2000;33:94-101.
10. Bhadia D, Bhadra S, Jain P and Jain NK. Pegnology; a review of PEGylated systems; Pharmazin. 2002;57:5-20.
11. Tiwari D K, Behari J and Sen P 2008 Application of Nanoparticles in Waste Water Treatment 3 417–33
12. Salavati-niasari M, Davar F and Mir N 2008 Synthesis and characterization of metallic copper nanoparticles via thermal decomposition Polyhedron 27 3514–8
13. Tai C Y, Tai C, Chang M and Liu H 2007 Synthesis of Magnesium Hydroxide and Oxide Nanoparticles Using a Spinning Disk Reactor 5536–41
14. Bhaviripudi S, Mile E, Iii S A S, Zare A T, Dresselhaus M S, Belcher A M and Kong J 2007 CVD Synthesis of Single-Walled Carbon Nanotubes from Gold Nanoparticle Catalysts 1516–7.
15. Joachim Allouche, Synthesis of Organic and Bioorganic Nanoparticles: An Overview of the Preparation Methods, Springer-Verlag London 2013; 27-30.
16. S. Tamizhrasi, A. Shukla, T. Shivkumar, V. Rathi, J. C. Rathi, Formulation and evaluation of Lamivudine loaded polymethacrylic acid nanoparticles, International Journal of PharmTech Research IJPRIF2009; 1:3: 411-415.
17. VJ Mohanraj and Y Chen, Research Article Nanoparticles – A Review, Tropical Journal of Pharmaceutical Research 2006; 5 :1: 561-573.
18. Saikat Das, Rinti Banerjee and Jayesh Bellare., Aspirin Loaded Albumin Nanoparticles by Coacervation: Implications in Drug Delivery, Trends Biomater. Artif Organs 2005; 18:2: 1-10.
19. Easha Biswas, Kalyan Kumar Banerjee, Sanat Karmakar, Sanmoy Karmakar, Tapan Kumar Pal. Preparation and Evaluation of Eprosartan Mesylate loaded PLGA Nanostructures. Research J. Pharm. and Tech 2022; 15(1):103-112.
20. M. Priya Chandana, M. Venkata Ramana, N. Rama Rao. Formulation and Evaluation of Valsartan Solid Lipid Nanoparticles. Journal of Drug Delivery & Therapeutics. 2021; 11(2-s):103-108.
21. Mahesh Gajanan Umbarkar, Pooja Sudhakar Rindhe Shivkanya Sanjay Chandrawanshi, Manoj J. Chavan, Vijay Manaskar. Formulation and Evaluation of Polymeric Nanoparticle by NanoPrecipitation Method. Journal of Drug Delivery & Therapeutics. 2020; 10(5-s):136-142.
22. Sujit Kumar Debnath, Srinivasan Saisivam, Monalisha Debanth, Abdelwahab Omri. Development and evaluation of Chitosan nanoparticles based dry powder inhalation formulations of Prothionamide. January 25, 2018.
23. A Supriya, J Sundaraseelan, BR Srinivas Murthy and M Bindu Priya. Formulation and Evaluation of Capsules of Asenapine Maleate Loaded Chitosan Nanoparticles. Volume 2 Issue 3 March 2018.
24. Muhammad Shafique, Mir Azam Khan, Waheed S. Khan, Maqsood-ur-Rehman, Waqar Ahmad,1 and Shahzeb Khan. Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability. 14 December 2017.
25. Babak Zolfagharnia, Elaheh Mortazavian , Davood Kaviani , Morteza Rafiee-Tehrani. Preparation and evaluation of nanoparticles composed of thiolated methylated pyridinyl chitosan as a new strategy for bucal drug delivery of insulin. Nanomed. J., 4(2): 83-88, Spring 2017.