Volume : 12, Issue : 01, January – 2025
Title:
ANTIDIABETIC ACTIVITY AND PHYTOCHEMICAL SCREENING OF EXTRACTS OF THE LEAVES OF CINNAMOMUM ZEYLANICUM ON ALLOXAN-INDUCED DIABETIC MICE
Authors :
G S Prajay*, Dr.D. Swathi, Dr.K. Nagasree, Dr.K. Shravankumar
Abstract :
In India, the number of people suffering from diabetes is believed to be rising steadily and the current antidiabetic therapies are frequently reported to have adverse side effects. Ethno medicinal plant use has shown promise for the development of cheaper, cost-effective antidiabetic agents with fewer side effects. Te aim of this study was to investigate the antidiabetic activity and mechanism of action of aqueous leaf extract prepared from Cinnamomum zeylanicum. Since this claim has not been investigated scientifically, the aim of this study was to evaluate the antidiabetic effect and phytochemical screening of alloxan-induced diabetic Mice.
The leaves of Cinnamomum zeylanicum have been used in traditional health systems to treat diabetes mellitus. However, the antidiabetic activity of this medicinal plant is not scientifically validated and authenticated. The present study aimed to investigate the in vitro and in vivo anti-diabetic activity of flower crude extract and solvent fractions of Cinnamomum zeylanicum.
The in vitro α–amylase inhibition of the crude extract and solvent fractions of Cinnamomum zeylanicum. Blood glucose lowering activity of 80% Ethanolic crude extract and solvent fraction was studied in animal models: Hypoglycemic mice model, oral glucose loaded mice model, dose-treated Alloxan -induced diabetic mice model. The effect of the crude extract on diabetic lipid profile was studied.
The acute toxicity study of Cinnamomum zeylanicum leaves extract did not show mortality in the animals at the limit dose during the observation period. The result of α–amylase enzyme inhibition activity was found in a dose-dependent manner, the strongest activity was shown by Crude extract fraction (89.60 % inhibition at 1000 μg/mL) compared to the standard acarbose having 97.19% inhibition at 1000 μg/mL. The crude extract of Cinnamomum zeylanicum showed significant blood glucose-lowering effect on hypoglycemic mice and oral glucose loaded mice. In Alloxan-induced diabetic mice model, the crude extract fraction significantly decreased the fasting blood glucose level after 14 days of treatment.
The result demonstrated the beneficial biochemical effects of Cinnamomum zeylanicum extract by inhibiting α–amylase improving serum lipid profile levels. The leaves crude extract are effective in lowering blood glucose levels in diabetic and hypoglycemic mice. The claimed traditional use as antidiabetic has scientific ground.
Key words: Diabetes mellitus, Herbal medicine, Cinnamomum zeylanicum, Alloxan, Anti diabetic activity.
Cite This Article:
Please cite this article in press G S Prajay et al., Antidiabetic Activity And Phytochemical Screening Of Extracts Of The Leaves Of Cinnamomum Zeylanicum On Alloxan-Induced Diabetic Mice.,Indo Am. J. P. Sci, 2025; 12 (01).
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